Summary
The cadmium concentration in kidney cortex (CdKc) was determined in 388 deceased persons, who at the time of death had lived in the cities of Düsseldorf and Duisburg, Federal Republic of Germany (FRG), and surrounding areas. The average CdKc concentration was found to be 17.1 μg/g wet weight. Individual values range from < 0.4 to 94.3 μg/g wet weight. The CdKc levels rapidly increase during the first decades of life. At the age of about 40 years, a plateau phase is reached. At high ages (> 70 years), the CdKc levels tend to decrease. Cigarette smokers have significantly higher CdKc concentrations than non-smokers. The increase of CdKc depends on the number of cigarettes smoked. Cigar and pipe smokers have slightly increased CdKc levels compared to non-smokers. Non-smokers who had spent the major part of their life in the area of Duisburg, a cadmium-polluted area, have, on the average, significantly higher CdKc levels than non-smokers from the less-polluted surrounding areas. In smokers the residential factor is masked by the effect of cigarette smoking.
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References
Balazova G, Rippel A, Rosival L (1979) Der Kadmiumgehalt in nekroptischem Material. In: F Bolck (ed), Kadmium-Symposium. Wissenschaftliche Beiträge der Friedrich-Schiller-Universität Jena, S 302–306
Drasch G (1982) Kadmium-Belastung im südbayerischen Raum. Münch Med Wochenschr 124:1129–1132
Drasch G (1983) An increase of cadmium body burden for this century — an investigation on human tissues. Sci Total Environ 26:111–119
Elinder CG, Kjellstróm R, Friberg L, Lind B, Linnman L (1976) Cadmium in kidney cortex, liver, and pancreas from Swedish autopsies. Arch Environ Health 31:292–302
Ellis KJ, Morgan WD, Zanzi I, Yasumara S, Vartsky D, Cohn SH (1981) Critical concentrations of cadmium in human renal cortex: dose-effect studies in cadmium smelter workers. J Toxicol Environ Health 7:691–703
Ellis KJ, Vartsky D, Zanzi I, Cohn SH (1979) Cadmium: in vivo measurement in smokers and non-smokers. Science 205:323–325
Ewers U, Brockhaus A, Dolgner R, Freier I, Jermann E, Bernard A, Stiller-Winkler, Hahn R, Manojlovic N (1985) Environmental exposure to cadmium and renal function of elderly women living in cadmium-polluted areas of the Federal Rupublic of Germany. Int Arch Occup Environ Health 55:217–239
Flanagan PR, McLellan JS, Haist J, Cherian GM, Chamberlain MJ, Valberg LS (1978) Increased dietary cadmium absorption in mice and human subjects with iron deficiency. Gastroeterol 74:841–846
Friberg L (1984) Cadmium and the kidney. Environ Health Perspect 54:1–11
Friberg L, Kjellström T (1981) Toxic metals — pitfalls in risk estimation. In: International Conference Heavy Metals in the Environment, Amsterdam 1981, CEP Consultants Edinburgh, pp 1–11
Friberg L, Piscator M, Nordberg GF, Kjellström LT (1974) Cadmium in the environment, 2nd edition. CRC Press, Cleveland, Ohio
Kjellström T (1979) Exposure and accumulation of cadmium in populations from Japan, the United States, and Sweden. Environ Health Perspect 28:169–197
Kjellström T, Elinder CG, Friberg L (1984) Conceptual problems in establishing the critical concentration of cadmium in human kidney cortex. Environ Res 33:284–295
Kowal E, Johnson DE, Kraemer DF, Pahren HR (1979) Normal levels of cadmium in diet, urine, blood, and tissues of inhabitants of the United States. J Toxicol Environ Health 5:995–1014
Lauwerys R, Hardy R, Job M, Buchet JP, Roels H, Bruaux P, Rondia D (1985) Environmental pollution by cadmium and cadmium body burden: an autopsy study. Toxicol Lett 23:278–289
MAGS (= Ministerium für Arbeit, Gesundheit und Soziales des Landes NW) (1982) Luftreinhalteplan Rheinschiene Mitte 1982–1986. Düsseldorf
MAGS (1985) Luftreinhalteplan Ruhrgebiet West, 1. Fortschreibung, 1984–1988 Düsseldorf
Ostergaard K (1977) The concentration of cadmium in renal tissue from smokers and nonsmokers. Acta Med Scand 202:193–195
Pandya CB, Parikh DJ, Patel TS, Kulkarni PK, Sathawara NG, Shah Shah GM, Chatterjee BB (1985) Accumulation and interrelationship of cadmium and zinc in human kidney cortex. Environ Res 36:81–88
Roels HA, Lauwerys RR, Buchet JP, Bernard A, Chettle DR, Harvey TC, Al-Haddad IK (1981) In vivo measurement of liver and kidney cadmium in workers exposed to this metal: its significance with respect to cadmium in blood and urine. Environ Res 26:217–240
Roels HA, Lauwerys RR, Dardenne AN (1983) The critical level of cadmium in human renal cortex: a re-evaluation. Toxicol Lett 15:357–360
Shaikh ZA, Smith JC (1980) Metabolism of orally ingested cadmium in humans. In: Holmstedt B, Lauwerys R, Mercier M, Roberfroid M (eds), Mechanisms of toxicity and hazard evaluation — Proceedings of the Second International Congress on Toxicology, Brussels 1980, pp 569–574
Stadt Duisburg (1985) Blei und Cadmium in Duisburg — Versuch einer Bilanz. Studie aus dem Chemischen und Lebensmitteluntersuchungsamt der Stadt Duisburg. Manuskript, Eigenverlag
Summer KH, Heilmaier H (1985) Metallothionein und Kadmium in der menschlichen Nierenrinde: Einfluß des Rauchens. In: Wege und Wirkungen von Umweltchemikalien. Tagung der Arbeitsgemeinschaft der Großforschungseinrichtungen (AGF) am 12. und 13. Dezember 1985 im Wissenschaftszentrum, Bonn — Bad Godesberg. Manuskript, Eigenverlag
Syversen TLM, Stray TK, Syversen GB, Ofstad J (1976) Cadmium and zinc in human liver and kidney. Scand J Clin Lab Invest 36:251–256
Thürauf JR, Schaller KH, Valentin H, Weltle D (1981) Zur gegenwärtigen Belastung der Bevölkerung mit Kadmium. Fortschr Med 99:1312–1317
Vahter M (1982) Assessment of human exposure to lead and cadmium through biological monitoring. National Swedish Institute of Environmental Medicine and Karolinska Institute, Department of Environmental Hygiene, Stockholm
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Hahn, R., Ewers, U., Jermann, E. et al. Cadmium in kidney cortex of inhabitants of North-West Germany: its relationship to age, sex, smoking and environmental pollution by cadmium. Int Arch Occup Environ Health 59, 165–176 (1987). https://doi.org/10.1007/BF00378494
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DOI: https://doi.org/10.1007/BF00378494