Summary
Experiments on rats were undertaken to determine the toxicity of calcium, barium, zinc, cadmium, and lead stearates. The threshold levels of acute toxicity of studied substances were determined, the toxicity decreased from Cd to Ca (Cd>Ba>Zn>Pbs>Ca). The cumulation coefficients, determined at the threshold level were 0.2–0.3. Intratracheal administration of 50 mg of studied substances caused different toxic effect: Cd>Ba>Ca>Zn>Pb. The pathologic processes were presented mainly in the lungs. Observation revealed the marked skin resorptive effect of all the stearates. Recommendations as to the protection of workers are given. The factual data are presented in 3 tables and 5 figures.
Similar content being viewed by others
References
Bienvenu, P., Nofre, Ch., Cier, A.: Toxicité generale comparee des ions métalliques. Relation avec la classification periodique. C.R.Acad.Sci.(Paris) 256, 1043 (1963)
Harding, H.E.: Some enquiries into the toxicology of zinc stearate. Brit.J. industr.Med. 15, 130 (1958)
Hausschild, F.: Pharmacologie und Grundlagen der Toxicologie. Leipzig: Thieme 1960
Kolla, V.E., Zalesov, V.S.: Relation of the chemical structure to toxicity among tinorganic compounds. In: Scienfic Papers of the State University in Perm (in Russian), Vol.III, pp.196–201. Perm: University Press 1964
Levina, E.I.: General toxicity of metals (in Russian). Leningrad: Medicine 1972
Mitina, L.S.: Experimental results of comparative toxicologic characteristics of organic compounds of barium. In: Hygienic science and practice (in Russian), pp.163–164. Moscow: The First Medical Institute 1972
Mogilevskaya, O.Ya.: Zinc and zinc oxide. In: Toxicology of rare metals (in Russian), pp.191–193. Moscow: Medicine 1963
Rosenthal, C.: Granulation in damp state. Offic.Activ.Plast et Caoutschouc 16, 41–44 (1969)
Savotsky, I.V.: A contribution to the evaluation of comparative toxicity of industrial toxins. In: Toxicology of new industrial products (in Russian), pp.7–19, Vol.9. Moscow: Medicine 1967
Schmidt, P., Gohlke, R., Nauman, H.: Tierexperimentelle Untersuchungen zur Toxizitat der Bleistearate. Int.Arch.Arbeitsmed. 26, 117–144 (1970)
Schmidt, P., Gohlke, R., Köhler, R., Wolff, R.: Zur akuten inhalativen Toxizitat von Kadmiumstearat. Z.ges.Hyg. 17, 308–317 (1971)
Shabalina, L.P.: Experimental contribution to ground of MPC of cadmium stearate in the air of working premises. In: Proceedings of the Conference of the Chairs of Hygiene of the First Medical Institute (in Russian), pp.70–72. Moscow: The First Medical Institute 1967
Shabalina, L.P.: Experimental investigation into the toxicity of bariumcadmium stearate (in Russian). Hygiene and Sanitation 2, 98–99 (1970)
Thinius, K.: Zum Stand der Kenntnis über die Toxizität der Stabili. Plaste und Kautschuk 5-6, 324–328 (1964)
Ulyanova, I.P., Kholopo, A.I., Eitengen, A.I.: Investigation into cumulative properties of chemical compounds at the threshold level as a basis for prognostication of chronic poisonings (in Russian). Hygiene of Labor and Occupational Diseases 3, 36–39 (1972)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tarasenko, N.Y., Shabalina, L.P. & Spiridonova, V.S. Comparative toxicity of metal stearates. Int. Arch Occup Environ Heath 37, 179–192 (1976). https://doi.org/10.1007/BF00378417
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00378417