Summary
Allergenicity of the dithiocarbamate fungicides maneb, mancozeb, zineb and their related compounds were evaluated from the guinea pig maximization test. Extreme to strong potency of allergenicity were revealed for maneb, mancozeb and zineb as well as one of their related compound lime sulphur mixture. But, such degree of allergenicity was not observed in cases of ethylene thiourea and dimethyl dithiocarbamic acid sodium salt. The cross sensitizations among maneb, mancozeb and zineb were estimated to be extreme in potentiality of causing contact sensitization, but there were not so dominant reactions in cases of other combinations tested.
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Matsushita, T., Arimatsu, Y. & Nomura, S. Experimental study on contact dermatitis caused by dithiocarbamates maneb, mancozeb, zineb, and their related compounds. Int. Arch Occup Environ Heath 37, 169–178 (1976). https://doi.org/10.1007/BF00378416
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DOI: https://doi.org/10.1007/BF00378416