Summary
Twenty male volunteers were exposed to 95 ppm trichloroethylene for 4h. Immediately before and after exposure and 4 h and 20h after cessation, some serum-enzymes, the cytoenzymological activity of the alkaline and acid phosphatases and the naphthol-AS-D-esterase in neutrophil granulocytes and the acid-base equilibrium were investigated. Compared with the control experiment, the activities of the three neutrophil enzymes increased during trichloroethylene exposure with high significance. No significant changes of the serum-enzymes and the acid-base equilibrium could be found.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bolt HM, Buchter A, Wolowski L, Gil DL, Bolt W (1977) Incubation of 14C-trichloroethylene vapor with rat liver microsomes. Uptake of radioactivity and covalent protein binding of metabolites. Int Arch Occup Environ Health 39:103–111
Fehr J, Großmann H-C (1978) Disparität von zirkulierendem und marginalem Granulozytenpool. Evidenz aus Studien über die alkalische Granulozytenphosphatase. Schweiz Med Wochenschr 108:1589
Fereberger W, Giessauf W, Robier FB, Schenk H (1978) Granulozytenfunktionsstorungen bei Dauerdialysepatienten. Haematol Blutransfus 21:377–381
Friborska A (1969) The phosphatases of peripheral white blood cells in workers exposed to trichloroethylene and perchloroethylene. Br J Ind Med 26:159–161
Goldberg AF, Barka T (1962) Acid phosphatase activity in human blood cells. Nature 193/194:297
Henschler D (1977) Gesundheitsschadliche Arbeitsstoffe. Verlag Chemie, Weinheim
Herbolsheimer R, Funk L (1974) Gaschromatographische Bestimmung von Trichlorathylen, Trichlorathanol, Trichloressigsaure und Athanol in einem Analysengang aus einer Probe. Arch Toxicol 32:209–215
Konietzko H, Elster I, Bencsath A, Drysch K, Weichardt H (1975 a) Psych omotorische Reaktionen unter definierter Trichlorathylenbelastung. Arch Toxicol 33:129–139
Konietzko H, Elster I, Bencsatz A, Drysch K, Weichardt H (1975 b) EEG-Veränderungen unter definierter Trichloräthylen-Exposition. Int Arch Occup Environ Health 35:257–264
Konietzko H (1979) Gesundheitsschäden durch Trichloräthylen. Fortschr Med 97:671–674
Leder LD (1964) Über die selektive fermentcytochemische Darstellung von neutrophilen myeloischen Zellen und Gewebsmastzellen im Paraffinschnitt. Klin Wochenschr 42:553
Merker H (1965) Die alkalische Leukozytenphosphatase. Ihre hamatologische und allgemeinklinische Bedeutung. Dtsch Med Wochenschr 90:484–486
Merker H (1962) Benzol und die Früherkennung seiner blutschädigenden Wirkung. Med Klin 57:1254–1262
Moszczynski P, Starek A, Slowinski S (1978) The activity of non-specific phosphatases und glycogen content of neutrophil granulocytes in individuals with occupational exposure to organic solvents of paints and varnishes. Wld Lek 18:1277–1281
Sigg RH (1966) Die semiologische Bedeutung cytochemischer Untersuchungen an Leukozyten. Schweiz Med Wochenschr 96:654
Stieglitz R, Stobbe H, Schuttmann W (1967) Knochenmarkschaden nach beruflicher Einwirkung des Insektizids gamma-Hexachlorcyclohexan (Lindan). Acta Haematol (Basel) 38:337–350
Uehleke H, Tabarelli-Poplawski S, Bonse G, Henschler D (1977) Spectral evidence for 2,2,3-trichlorooxirane formation during microsomal trichloroethylene oxidation. Arch Toxicol 37:95–105
Uehleke H, Poplawski-Tabarelli S (1977) Irreversible binding of 14C-labelled trichloroethylene to mice liver constituents in vivo and in vitro. Toxicology 37:289–294
Zeya HI, Keku E, Richards F, Spurr CL (1979) Monocyte and granulocyte defect in chronic leukemia. Am J Pathol 95:43–53
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Konietzko, H., Reill, G. The effect of trichloroethylene on some serum-enzymes, on the cytoenzymological activity in leucocytes, and on the acid-base equilibrium. Int. Arch Occup Environ Heath 47, 61–67 (1980). https://doi.org/10.1007/BF00378329
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00378329