Summary
Pulmonary effects were investigated in 106 toluene diisocyanate (TDI)-exposed workers and 39 referents in 1980 and in 64 exposed workers and 21 referents on the 2-year follow-up study in 1982. Means of individual, time-weighted average (TWA) exposure concentrations measured by personal monitors were approximately 0.001 ppm in each year. Short-term exposure at 0.02 ppm or over was observed in 9.3% of the collected samples in 1980 and 1.9% in 1982. Pulmonary function was assessed by measurements of maximum expiratory flow-volume curve and respiratory impedance. No differences were observed in the means of the pulmonary functions and their individual daily changes between the TDI workers and the referents. Significant intra-individual, two-year decreases were observed in some pulmonary function parameters in both groups, but when the effect of aging was adjusted, the decreases disappeared. Prevalences of respiratory symptoms in the TDI workers were not significantly higher than those in the referents, except for irritating complaints of the eyes and throat probably due to peak exposure to TDI and/or co-existing irritants. Eight of the TDI workers had episodes of acute asthmatic reactions shortly after having begun their TDI jobs and most parameters in their maximum expiratory flow were significantly less than the predicted values, though exposure concentrations when the episodes occurred could not be defined. From these results, it was suggested that TDI exposure at the levels of 0.001 ppm may not induce adverse pulmonary effects when the workers are not hypersusceptive to TDI.
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References
Adams WGF (1975) Long-term effects on health of men engaged in the manufacture of tolylene diisocyanate. Br J Ind Med 32:72–78
American Conference of Governmental Industrial Hygienists (1984) Threshold limit values for chemical substances and physical agents in the work environment with intended changes for 1983–1984, Cincinnati, Ohio, USA
American Thoracic Society (1962) Chronic bronchitis, asthma, and pulmonary emphysema. Am Rev Respir Dis 85:762–768
Avery SB, Stetson DM, Pan PM, Mathews KP (1969) Immunological investigation of individuals with toluene diisocyanate asthma. Clin Exp Immunol 4:585–596
Butcher BT, Karr RM, O'Neil CE, Wilson MR, Dharmarajan V, Salvaggio JE, Weil H (1979) Inhalation challenges and pharmacologic studies of toluene diisocyanate (TDI)sensitive workers. J Allergy Clin Immunol 64:146–152
CIBA guest symposium (1959) Terminology, definitions, and classification of chronic pulmonary emphysema and related conditions. Thorax 14:286–299
Connoly CK (1979) Diurnal rhythms in airway obstruction. Br J Dis Chest 73:357–366
Goldman M, Knudson RJ, Mead J, Peterson N, Schwaber JR, Wohl ME (1970) A symplified measurement of respiratory resistance by forced oscillation. J Appl Physiol 28:113–116
Hetzel MR, Clark TJH (1980) Comparison of normal and asthmatic circadian rhythms in peak expiratory flow rate. Thorax 35:732–738
10.Japan Association of Industrial Health (1983) Recommendation of threshold limit values. Jpn J Ind Health 25:288–302
Kanner RE, Morris AH (eds) (1975) Clinical pulmonary testing: a manual of uniform laboratory procedures for the intermountain areas. Intermountain Thoracic Society, Salt Lake City
Karol MH, Ioset HH, Alarie Y (1978) Tolyl-specific IgE antibodies in workers with hypersensitivity to toluene diisocyanate. Am Ind Hyg Assoc J 39:454–458
Karol MH, Sandberg T, Riley EJ, Alarie Y (1979) Longitudinal study of tolyl-reactive IgE antibodies in workers hypersensitivity to TDI. JOM 21:354–358
McKay RT, Brooks SM (1983) Effect of toluene diisocyanate on beta adrenergic receptor function. Am Rev Respir Dis 128:50–53
Medical Research Council (1965) Definition and classification of chronic bronchitis for clinical and epidemiological purposes. Lancet 1:775–779
Medical Research Council (1976) Questionnaire on respiratory symptoms. Medical Research Council, London
Musk AW, Peters JM, Dißerardinis L, Murphy RLH (1982) Absence of respiratory effects in subjects exposed to low concentrations of TDI and MDI. JOM 24:746–750
Nakadate T (1981) A practical redesign of forced oscillatory device and its epidemiological use in rural population I. Some consideration in redesign for measuring human respiratory impedance. Keio Igaku 58:737–745 (Jpn)
Nicholas HR (1983) Occupational asthma: a narrow spectorum. JOM 25:77
O'Brien IM, Harries MG, Burge PS, Pepys J (1979) Toluene diisocyanate induced asthma 1. Reaction to TDI, MDI, HDI, and histamine. Clin Allergy 9:1–6
O'Brien IM, Newman-Taylor A, Burge PS, Harries MG, Fawcett IW, Pepys J (1979) Toluene di-isocyanate induced asthma 11. Inhalation challenge tests and bronchial reactivity studies. Clin Allergy 9:7–15
Peters JM, Murphy RLH, Ferris Jr BG (1969) Ventilatory function in workers exposed to low levels of toluene diisocyanate: a six-month follow-up. Br J Ind Med 26:115–120
Peters JM, Murphy RLH, Pagnotto L, Whittenberger JL (1970) Respiratory impairment in workers exposed to “safe” levels of toluene diisocyanate (TDI). Arch Environ Health 20:364–367
Reilly DA (1968) A test-paper method for the determination of toluene diisocyanate vapor in air. Analyst 93:178–185
Wegman DH, Peters JM, Pagnotto L, Fine LJ (1977) Chronic pulmonary function loss from exposure to toluene diisocyanate. Br J Ind Med 34:196–200
Weill H, Butcher B, Diem JE, Dharmarajan V, Glindmeyer H, Jones R, O'Neil C, Salvaggio J (1981) Respiratory and immunologic evaluation of isocyanate exposure in a new manufacturing plant. NIOSH Pub. 81-125, Washington, D.C.
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Omae, K. Two-year observation of pulmonary function in workers exposed to low concentrations of toluene diisocyanate. Int. Arch Occup Environ Heath 55, 1–12 (1984). https://doi.org/10.1007/BF00378062
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DOI: https://doi.org/10.1007/BF00378062