Unexpected decrease in cytogenetic biomarkers frequencies observed after increased exposure to organophosphorus pesticides in a production plant

  • Ch. Laurent
  • P. Jadot
  • Ch. Chabut


Public Health Production Plant Environmental Medicine Organophosphorus Pesticide Unexpected Decrease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Degraeve N, Moutschen J (1983) Genotoxicity of an organophosphorus insecticide dimethoate, in the mouse. Mutation Research, 119:331–337Google Scholar
  2. 2.
    Georgian L et al. (1983) Cytogenetic effects of alachlor and mancozeb. Mutat Res 116:341–348Google Scholar
  3. 3.
    Amer SM, Aboul-ela EI (1985) Cytogenetic effects of pesticides:induction of micronuclei in mouse bone marrow by the insecticides cypermethrin and rotenone. Mutat Res 155:135–142Google Scholar
  4. 4.
    Wang TC et al. (1987) Induction of sister chromatid exchanges by pesticides in primary rat tracheal epithelial cells and chinese hamster ovary cells. Mutat Res 188:311–321Google Scholar
  5. 5.
    Salvadori DMF et al. (1988) Cytogenetic effect of malathion insecticide on somatic and germ cells of mice. Mutat Res 204:283–287Google Scholar
  6. 6.
    Pandita TK (1988) Assessment of the mutagenic potential of a fungicide Bavistin using multiple assays. Mutat Res 204:627–643Google Scholar
  7. 7.
    Kappas A et al. (1990) Genotoxic studies on the organophosphorus insecticide chloracetophone. Mutat Res 240:203–208Google Scholar
  8. 8.
    Meschini R et al. (1988) Chromosomal damage induced by maleic hydrazide in mamalian cells in vitro and in vivo. Mutat Res 204:645–648Google Scholar
  9. 9.
    Gonzalez Cid M (1988) Nitroso-aldicarb induces sister chromatid exchanges in human lymphocytes in vitro. Mutat Res 204:665–668Google Scholar
  10. 10.
    Garriot ML et al. (1991) Genotoxic studies on the preemergence herbicide trifluralin. Mutat Res 260:187–193Google Scholar
  11. 11.
    Yoder J et al. (1973) Lymphocytes chromosome analysis of agricultural workers during extensive occupational exposure to pesticides. Mutat Res 21:335–340Google Scholar
  12. 12.
    Czeizel A et al. (1975) Studies of chromosomal mutations in workers producing organophosphate insecticides. Mutat Res 29:279–284Google Scholar
  13. 13.
    Kirali J et al. (1979) Chromosome studies in workers producing organophosphate insecticides. Arch Environ Contamin Toxicol 8:309–319Google Scholar
  14. 14.
    Nehez M et al. (1981) Data of the chromosome examinations of workers exposed to pesticides. Regulat Toxicol Pharmacol 1:116–122Google Scholar
  15. 15.
    Dulout F et al. (1985) Sister chromatid exchanges and chromosomal aberrations in a population exposed to pesticides. Mutat Res 143:237–244Google Scholar
  16. 16.
    Paldi A et al. (1987) Cytogenetic studies on rural populations exposed to pesticides. Mutat Res 187:127–132Google Scholar
  17. 17.
    Rupa D et al. (1989) Frequencies of chromosomal aberrations in smokers exposed to pesticides in cotton fields. Mutat Res 222:37–41Google Scholar
  18. 18.
    Rupa D et al. (1989) Analysis of Sister chromatid exchanges, cell kinetics and mitotic index in lymphocytes of smoking pesticides sprayers. Mutation Research 233:253–258Google Scholar
  19. 19.
    De Ferrari M et al. (1991) Cytogenetic biomonitoring of an Italian population exposed to pesticides: chromosome aberration and sister chromatid exchanges analysis in peripheral blood lymphocytes. Mutat Res 260:105–113Google Scholar
  20. 20.
    Kourakis A et al. (1992) Frequencies of chromosomal aberrations in pesticide sprayers working in plastic green houses. Mutat Res 279:145–148Google Scholar
  21. 21.
    Bolognesi C et al. (1993) Frequencies of micronuclei in lymphocytes from a group of floriculturists exposed to pesticides. Toxicol Environ Health 40:405–411Google Scholar
  22. 22.
    Carrano AV, Moore DH (1982) The rationale and methodology for quantifying sister chromatid exchanges in human. In: Buetow DE, Cameron IL, Padilla GM, Zimmerman AM (eds.) Mutagenicity: new horizons in genetic toxicology, Academic Press, New York, pp 268–299Google Scholar
  23. 23.
    Carrano AV (1982) Sister chromatid exchanges as an indicator of human exposure. In: Bridges BA (ed) Bandbury report 13: Indicators of genotoxic exposure, Cold Spring Harbor, New York, pp 307–318Google Scholar
  24. 24.
    Carrano AV, Natarajan AT (1988) Considerations for population monitoring using cytogenetic techniques. Mutat Res 204:379–407Google Scholar
  25. 25.
    Laurent C et al. (1984) Sister chromatid exchanges frequency in workers exposed to high levels of ethylene oxide, in an hospital sterilization service. Int Arch Occup Environ Health 54:33–43Google Scholar
  26. 26.
    Gu ZW et al. (1981) Effets du trichloréthylène et ses métabolites sur le taux d'échanges entre chromatides-soeurs. Ann Génétiques 36:276–280Google Scholar
  27. 27.
    Kelsey KT et al. (1991) Bimodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. II relationship to baseline SCEs frequency. Mutat Res 248:27–33Google Scholar
  28. 28.
    Bender MA et al. (1988) Chromosomal aberrations and sister chromatid exchanges frequencies in peripheral blood lymphocytes of a large human population sample. Mutat Res 204:421–433Google Scholar
  29. 29.
    Laurent C (1991) Application of the Sister Chromatid Exchanges Methodology for Biomonitoring Human Exposed to Environmental Mutagens. In: Environmental Mutagens, Carcinogens and Teratogens: Principles and Short Term Assay. Chiang Maï Star Press. pp 246–273Google Scholar
  30. 30.
    Lambert B, Lindblad A (1978) Increased frequency of sister chromatid exchanges in cigarette smokers. Hereditas, 88:147–149Google Scholar
  31. 31.
    Murthy BK, Prema nn (1979) Frequency of sister chromatid exchange in cigarette smokers. Hum Genet 52:343–348Google Scholar
  32. 32.
    Lambert B et al. (1982) Sister chromatid exchanges. John Wiley and Sons, New York, pp 149–182Google Scholar
  33. 33.
    Sarto S et al. (1985) Aging and smoking increase the frequency of sister chromatid exchanges in man. Mutat Res 144:183–187Google Scholar
  34. 34.
    Sarto F et al. (1987) Variations of SCEs frequencies of exsmokers. Mutat Res 192:157–162Google Scholar
  35. 35.
    Hollander DH et al. (1978) SCE in the peripheral blood of cigarettes smokers and in lung cancer patients and the effect of chemotherapy. Hum Genet 44:165–168Google Scholar
  36. 36.
    Garry VF et al. (1979) Ethylene Oxide: evidence of human chromosomal effects. Environ Mutagenes 1:375–382Google Scholar
  37. 37.
    Hedner K et al. (1983) SCE and chromosome aberrations in relation to smoking in 91 individuals. Hereditas 98:77–81Google Scholar
  38. 38.
    Laurent C (1988) SCE increases after an accidental acute inhalation exposure to EtO and recovery to normal after 2 years. Mutat Res 204:711–717Google Scholar
  39. 39.
    Sorsa M (1984) Monitoring of Sister chromatid exchanges and micronuclei as biological endpoints. In: Berlin A, Draper N, Hemminki K, Vainio H (eds) Monitoring human exposure to carinogenic and mutagenic agents. IARC scientific publications. No 59. International Agency for Research on Cancer, Lyon, pp 339–349Google Scholar
  40. 40.
    Laurent C (1986) Les échanges entre chromatides-soeurs (SCEs), test de mutagenèse appliqué en Médecine préventive et dans le domaine de la santé publique. University of Liège, Faculty of Medicine (eds) Thèse de Doctorat en Sciences Biomédicales Expérimentales, pp 1–240Google Scholar
  41. 41.
    Laurent C (1989) A sensitive approach for biomonitoring human exposed to mutagens: the Sister Chromatid Exchanges methodology. Ziekenhuis Farmacie 5:147–152Google Scholar
  42. 42.
    Nichols nn et al. (1988) Paradoxical changes in SCE frequencies persistently elevated in vivo on exposure to a mutagen in vitro. Mutat Res 204:445–449Google Scholar
  43. 43.
    Chen H et al. (1981) Induction of sister chromatid exchanges and cell cycle delay in cultured mammalian cells treated with eight organophosphorus pesticides. Mutat Res 88:307–316Google Scholar
  44. 44.
    Chen H et al. (1981) Sister Chromatid Exchanges and cell cycle delay in Chinese hamster V79 cells treated with organophosphorus compounds (eight pesticides and one defoliant). Mutat Res 88:307–316Google Scholar
  45. 45.
    Chen H et al. (1982) Sister chromatid exchanges in Chinese hamster cells treated with seventeen organophosphorus compounds in the presence of a metabolic activation system. Environ Mutagenes 4:621–624Google Scholar
  46. 46.
    Sobti R et al. (1982) Cytokinetic and cytogenetic effects of some agricultural chemicals on human lymphoid cells in vitro: organophosphates. Mutat Res 102:89–102Google Scholar
  47. 47.
    Rupa D et al (1991) Frequency of sister chromatid exchange in peripheral lymphocytes of malepesticide applicators. Environ Molec Mutagenes 18:136–138Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Ch. Laurent
    • 1
  • P. Jadot
    • 1
  • Ch. Chabut
    • 1
  1. 1.Oncology, Radiobiology and Experimental Mutagenesis (ORME) LaboratoryUniversity of Liège, Institute of Pathology B-23Sart TilmanBelgium

Personalised recommendations