Skip to main content
Log in

The molecular epidemiology of occupational carcinogenesis in vinyl chloride exposed workers

  • Published:
International Archives of Occupational and Environmental Health Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Brandt-Rauf PW, et al. (1995) The molecular epidemiology of growth signal transduction proteins. J Occup Environ Med 37:77–83

    Google Scholar 

  2. Brandt-Rauf PW, et al. (1995) Mutant p21 protein as a biomarker of chemical carcinogenesis in humans. In: Mendelsohn ML, Peeters JP, Normandy MJ (eds) Biomarkers and Occupational Health: Progress and Perspectives. Washington, D.C., Joseph Henry Press, pp 163–173

    Google Scholar 

  3. Agency for Toxic Substances and Disease Registry (1993) Toxicological Profile for Vinyl Chloride. TP-92/20. Atlanta, USDHHS/PHS

  4. Barbin A, Bartsch M (1986) Mutagenic and promutagenic properties of DNA adducts formed by vinyl chloride metabolites. In: Singer B, Bartsch H (eds) The Role of Cyclic Nucleic Acid Adducts in Carcinogenesis and Mutagenesis. Lyon, IARC, pp 345–358

    Google Scholar 

  5. Swenberg JA, et al. (1992) Etheno adducts formed in DNA of vinyl chloride-exposed rats are highly persistent in liver. Carcinogenesis 13:727–729

    Google Scholar 

  6. Barbacid M (1987) Ras genes. Ann Rev Biochem 56:779–827

    Google Scholar 

  7. Marion M-J, et al. (1993) Ras gene as a molecular epidemiologic marker in human cancers induced by chemicals. Proceedings of the International Congress on Occupational Health 24:175

    Google Scholar 

  8. Marion M-J, et al. (1991) Activation of Ki-ras gene by point mutations in human liver angiosarcoma associated with vinyl chloride exposure. Molec Carcinogen 4:450–454

    Google Scholar 

  9. Bos JL, et al. (1985) Amino acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukemia. Nature 315:726–730

    Google Scholar 

  10. Pincus MR, et al. (1985) Correlation of structure with transforming activity of the p21 proteins with substitutions of Lamino acids for Gly at position 13. J Protein Chem 4:345–352

    Google Scholar 

  11. LaVecchio JA, et al. (1990) Characterization of monoclonal antibodies specific to the activated ras p21 with aspartic acid at position 13. Oncogene 5:1173–1178

    Google Scholar 

  12. Soussi T, et al. (1994) Multifactorial analysis of p53 alteration in human cancer: a review. Int J Cancer 57:1–9

    Google Scholar 

  13. Hollstein M, et al. (1994) P53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis 15:l-3

    Google Scholar 

  14. Gannon JV, et al. (1990) Activating mutations in p53 produce a common conformational effect-a monoclonal antibody specific for the mutant form. EMBO Journal 9:1595–1602

    Google Scholar 

  15. DeVivo I, et al. (1994) Mutant c-Ki-ras p21 protein in chemical carcinogenesis in humans exposed to vinyl chloride. Cancer Causes Control 5:273–278

    Google Scholar 

  16. Smith S, et al. (1996) Mutant p53 protein as a biomarker of chemical carcinogenesis in humans. J Occup Environ Med (in press)

  17. Heldaas SS, et al. (1984) Incidence of cancer among vinyl chloride workers. Br J Industr Med 41:25–30

    Google Scholar 

  18. Luo J-C, et al. (1995) Levels of p53 antigen in the plasma of patients with adenomas and carcinomas of the colon. Cancer Lett 91:235–240

    Google Scholar 

  19. Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759–761

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marion, M.J., De Vivo, I., Smith, S. et al. The molecular epidemiology of occupational carcinogenesis in vinyl chloride exposed workers. Int Arch Occup Environ Health 68, 394–398 (1996). https://doi.org/10.1007/BF00377858

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00377858

Keywords

Navigation