The biological half-time of heavy metals

The existence of a third, “slowest” Component

Summary

Concentrations of Cd (475 samples), Pb (271), and total Hg (166) were determined in the organs and tissues during autopsies of inhabitants of the Tokyo metropolitan area who had experienced no known exposure to an abnormally high level of heavy metals and had died sudden deaths by accident. The results of this study do not differ greatly from those of other reports. Based on the intraorganic accumulation of the heavy metals according to age when they were not experimentally administered, the biological half-time (BHT) was estimated using a mathematical model with differential equations. It was hypothesized that the input of heavy metals into organs is proportional to the amount of food intake according to age (assuming little or no chronological change of heavy metals concentrations in food over several decades), and that the output is proportional to the intraorganic accumulation. The resulting BHT was very long, 10 to 100 times that computed in a number of studies from observation of the attenuation curve for a relatively short period after the experimental adminstration of heavy metals to humans or animals.

The author devised a model consisting of two series compartments in one organ: the superficial, where heavy metals enter directly and are weakly bound with protein, and the profound, where they enter only via the superficial compartment to be strongly bound with the constituents. It was elucidated theoretically that the short BHT obtained by heavy metal administration is associated only with the superficial compartment of the organ, and that the long BHT obtained without experimental administration of heavy metals is due to the detour circuit from the superficial to the profound compartments. The ratio of the short BHT to the long BHT is the proportion of the content of a heavy metal in the superficial compartment to the total content in the whole organ. In order to prove the existence of the two compartments, superficial and profound, and to compute their ratios, further studies should be performed. The attenuation curve of the concentration, or of the amount after a single administration of a heavy metal, consists of the rapid component (first) and the slow component (second). The latter has been generally used for computation of BHTs. The slowest component is frequently present several years after the first two. There is a fair chance that the BHT based on the slowest component agrees with the BHT found in the present study.

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References

  1. 1.

    Aberg, B., Ekman, L., Falk, R., Greitz, U., Persson, G., Snihs, J. O.: Metabolism of methylmercury (203 Hg) compounds in man. Arch. Environ. Hlth. 19,478–484 (1969)

    Google Scholar 

  2. 2.

    Bakir, F., Damluji, S. F., Amin-Zaki, L., Murtadha, M., Rhalidi, A., AL-Rawi, N. Y., Tikriti, S., Dhahir, H. I., Clarkson, T. W., Smith, J. C., Doherty, R. A.: Methylmercury poisoning in Iraq. Science 181, 230–241 (1973)

    Google Scholar 

  3. 3.

    Barry, P. S. I., Mossman, D. B.: Lead concentration in human tissues. Brit. J. Ind. Med. 27, 339–351 (1970)

    Google Scholar 

  4. 4.

    Barry, P. S. I.: A comparison of concentrations of lead in human tissues. Brit. J. Ind. Med. 32, 119–139 (1975)

    Google Scholar 

  5. 5.

    Bolanowska, W., Piotrowski, J., Trojanowska, B.: Kinetics of distribution and excretion of lead (Pb-210) in rats. I. The distribution of a single intravenous dose. Med. Pracy 18, 29–41 (1967) [in Polish with English summary]

    Google Scholar 

  6. 6.

    Bolanowska, W., Piotrowski, J.: Kinetics of distribution and excretion of lead (Pb-210) in rats. II. Excretion of a single intravenous lead dose. Med. Pracy 19, 133–142 (1968) [in Polish with English summary]

    Google Scholar 

  7. 7.

    Bolanowska, W., Piotrowski, J.: Kinetics of distribution and excretion of lead (Pb-210) in rats. III. The retention and excretion of lead given in daily intravenous injections. Med. Pracy 20, 494–503 (1969) [in Polish with English summary]

    Google Scholar 

  8. 8.

    Draper, N. R., Smith, H.: Applied regression analysis. New York: John Willey and Sons 1966

    Google Scholar 

  9. 9.

    Friberg, L., Vostal, J.: Mercury in the Environment. Cleveland: CRC Press 1972

    Google Scholar 

  10. 10.

    Friberg, L., Piscator, M., Nordberg, G. F., Kjellström, T.: Cadmium in the Environment. (2nd ed.), Cleveland: CRC Press 1974

    Google Scholar 

  11. 11.

    Gross, S. B., Pfitzer, E. A., Yeager, D. W., Kehoe, R. A.: Lead in human tissues. Toxicol. Appl. Pharm. 32, 638–651 (1975)

    Google Scholar 

  12. 12.

    Imbus, H. R., Cholak, J., Miller, L. H., Sterling, T.: Boron, cadmium, chromium and nickel in blood and urine. Arch. Environ. Hlth. 6, 286–295 (1963)

    Google Scholar 

  13. 13.

    Kitamura, S., Kondo, M., Takizawa, Y., Fujii, M.: Mercury. Tokyo: Kodansha 1976 [in Japanese]

    Google Scholar 

  14. 14.

    Kjellström, T., Nordberg, G.F.: A kinetic model of cadmium metabolism in the human being (to be published)

  15. 15.

    Mitsui, T.: Mesurements of renal cortex and medulla from Japanese twins. Keio Igaku 25, 18–22 (1948) [in Japanese]

    Google Scholar 

  16. 16.

    Mori, M.: Handbook of anatomy (Kaibogaku Yoran), Tokyo: Nanzando Book Co. 1960 [in Japanese]

    Google Scholar 

  17. 17.

    Nomiyama, K.: Critical concentration and biological half-time of cadmium in the renal cortex of humans. Kankyo Hoken Report (Environmental Health Report) 36, 62–65 (1976) [in Japanese]

    Google Scholar 

  18. 18.

    Nomiyama, K. Nomiyama, H.: Biological half time of cadium in rabbits. Jap. J. Hyg. 31, 78 (1976) [in Japanese]

    Google Scholar 

  19. 19.

    Nomiyama, K., Nomiyama, H., Taguchi, T.: Biological half time of cadmium in mice. Jap. J. Hyg. 32, 128 (1977) [in Japanese]

    Google Scholar 

  20. 20.

    Prickett, C. S., Laug, E. P., Kunze, F. M.: Distribution of mercury in rats following oral and intravenous adminstration of mercuric acetate and phenylmercuric acetate. Proc. Soc. Exp. Biol. Med. 73, 585–588 (1950)

    Google Scholar 

  21. 21.

    Rabinowitz, M. B., Wetherill, G. W.: Lead metabolism in the normal human: Stable isotopes studies. Science 182, 725–727 (1973)

    Google Scholar 

  22. 22.

    Rahola, T., Aaran, R.K., Miettinen, J. K.: Half-time studies of mercury and cadmium by whole body counting. I.A.E.A. Symposium on the Assessment of Radioactive organ and body burdens, Stockholm, November 22–26, 1971 (in Assessment of Radioactive Contamination in Man, I.A.E.A., Vienna, 1972, p. 553)

    Google Scholar 

  23. 23.

    Section of Nutrition, Bureau of Public Health, Ministry of Health and Welfare: Newly adopted nutritional requirement of the Japanese, Toyko: Daiichi Shuppan Book Co. 1961 [in Japanese]

    Google Scholar 

  24. 24.

    Sudo, Y., Nomiyama, K.: Long-term observations on urinary cadmium excretion of a former cadmium worker. Jap. J. Ind. Hlth. 14, 117–122 (1972) [in Japanese with English summary]

    Google Scholar 

  25. 25.

    Sumino, K., Hayakawa, K., Shibata, T., Kitamura, S.: Heavy metals in normal Japanese tissues. Arch. Environ. Hlth. 30, 487–494 (1975)

    Google Scholar 

  26. 26.

    Takabatake, E., Shigematsu, I., Kuzuhara, Y.: Cadmium concentration of grains and noodle in old ages (personal communication)

  27. 27.

    Teisinger, J., Přerovská, I., Šedivec, V., Flek, J., Roth, Z.: Attempt on determination of biologically active lead in organism in experimental poisoning. Int. Arch. Gewerbepath. Gewerbehyg. 25, 240–255 (1969)

    Google Scholar 

  28. 28.

    Tsuchiya, K., Sugita, M.: A mathematical model for deriving the biological half-life of a chemical. Nord. Hyg. Tidskr. 53, 105–110 (1971)

    Google Scholar 

  29. 29.

    Tsuchiya, K., Uchiyama, G., Sugita, M.; Yasuda, K.: Total mercury concentration in cerebrum, cerebellem, hair and urine from “normal” Japanese people. Jap. J. Hyg. 30, 50 (1975) [in Japanese]

    Google Scholar 

  30. 30.

    Tsuchiya, K., Sugita, M., Seki, Y.: Methematical derivation of the biological half-time of cadmium in human organs based on the accumaltion of the metal in the organs. Keio J. Med. 25, 73–82 (1976)

    Google Scholar 

  31. 31.

    Tsuchiya, K., Sugita, M.: Some problems and questions in the derivation of biological halftime of a chemical. Kankyo Hokon Report (Environmental Health Report) 36, 70–71 (1976) [in Japanese]

    Google Scholar 

  32. 32.

    Yamagata, N., Iwashima, K., Nagai, T.: Gastrointestinal absorption of ingested 115mCd by man. Bull. Inst. Publ. Hlth. 24, 1–6 (1975)

    Google Scholar 

  33. 33.

    Yagyu, H., Ohi, G., Nishigaki, S., Seki, H.: Studies on biological half life of alkyl mercury compounds in rats and mice. Jap. J. Hyg. 30, 55 (1975) [in Japanese]

    Google Scholar 

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Sugita, M. The biological half-time of heavy metals. Int. Arch Occup Environ Heath 41, 25–40 (1978). https://doi.org/10.1007/BF00377797

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Key words

  • Biological half-time of heavy metals
  • Cadmium
  • Lead
  • Mercury
  • Heavy metal accumulation by age
  • Metabolism of heavy metals
  • Heavy metals in organs