Summary
Genetic polymorphisms of HLA antigens and HLA-linked serum complement components (C2, C4A, C4B and BF) were investigated in 79 Japanese patients suffering from psoriasis. HLA typing revealed increased frequencies of HLA-A1, A2, B39, Bw46, Cw6, Cw7 and Cw11. Among complement components, positive associations were obtained with C4A4 and C4B2 and a negative association with BFF. The major histocompatibility complex haplotype (supratype), HLA-A2-Cw11-Bw46-C2C-BFS-C4A4-C4B2-DRw8 is purported to be a new high-risk haplotype in Japanese patients with psoriasis. Analysis of patients with this supratype via pulsed field gel electrophoresis showed the existence of specific, extensive DNA deletions near HLA-DR genes, but no disease-specific patterns could be observed by means of this technique. The newly-found high-risk haplotype indicates racial and ethnic differences among psoriatic patients.
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References
Anand R (1986) Pulsed field gel electrophoresis: a technique for fractionating large DNA molecules. Trends Genet 23:278–285
Aoki T (1971) Psoriasis in Japan. Arch Dermatol 104:328–329
Brenner W, Gschnait F, Mayr WR (1978) HLA B13, B17, B37 and Cw6 in psoriasis vulgaris. Association with the age of onset. Arch Dermatol Res 262:337–339
Dewald G, Lange CE, Schmeel E, Kreysel HW (1983) HLA-linked complement polymorphisms (C2, BF) in psoriasis. Arch Dermatol Res 275:301–304
Dewald G, Nakagawa H, Tokunaga K, Ishibashi Y, Omoto K (1987) Properdin factor B allotypes in Japanese patients with psoriasis. J Dermatol (Tokyo) 14:233–236
Henseler T, Christophers E (1985) Psoriasis of early and late onset. Characterization of two types of psoriasis vulgaris. J Am Acad Dermatol 13:450–456
Itakura K, Moriuchi J, Wakisaka A, Nakai Y, Kano T, Aizawa M (1980) Psoriasis vulgaris and HLA in Japanese. In: Terasaki PI (ed) Histocompatibility testing. UCLA Tissue Typing Center, Los Angeles, p 950
Mauff G, Alper CA, Awdeh ZL, Batchelor JR, Bertrams J, Bruun-Petersen G, Dawkins RL, Démant P, Edwards J, Gross-Wilde H, Hauptmann G, Klouda P, Lamm L, Mollenhauer E, Nerl C, Olaisen B, O'Neill G, Rittner C, Roos MH, Skanes V, Teisberg P, Wells L (1983) Statement on the nomenclature of human C4. Immunobiology 164:184–191
Nakagawa H, Asahina A, Akazaki S, Tokunaga K, Matsuki K, Ishibashi Y, Juji T (1990) Association of Cw11 in Japanese patients with psoriasis vulgaris. Tissue Antigens 36:241–242
Ohkido M, Ozawa A, Nakagawa M, Tsuji K (1982) HLA-Cw6 in Japanese psoriasis vulgaris. In: Farber EM, Cox AJ (eds) Psoriasis: Proceedings of the Third International Symposium. Grune & Stratton, New York, pp 287–288
Ozawa A, Ohkido M, Tsuji K (1981) Some recent advances in HLA and skin diseases. J Am Acad Dermatol 4:205–230
Ozawa A, Ohkido M, Inoko H, Ando A, Tsuji K (1988) Specific restriction fragment polymorphism on the HLA-C region and susceptibility to psoriasis vulgaris. J Invest Dermatol 90:402–405
Rittner C, Bertrams J (1981) On the significance of C2, C4, and factor B polymorphism in disease. Hum Genet 56:235–247
Sim E, Cross SJ (1986) Phenotyping of human complement C4, class III HLA antigen. Biochem J 239:763–767
Thomas RJ (1977) Psoriasis case rate HLA antigen frequency correlations. Dermatologica 154:23–31
Tiilikainen A, Lassues A, Karvonen J, Vartiainen P, Julin M (1980) Psoriasis and HLA-Cw6. Br J Dermatol 102:179–184
Tokunaga K, Araki C, Juji T, Omoto K (1981) Genetic polymorphism of the complement C2 in Japanese. Hum Genet 58:213–216
Tokunaga K, Araki C, Juji T, Omoto K (1982) Polymorphism of properdin factor B in Japanese. Description of a rare variant and data of association with HLA and C2. Hum Genet 62:42–45
Tokunaga K, Omoto K, Akaza T, Akiyama N, Amemiya H, Naito S, Sasazuki T, Satoh H, Juji T (1985) Haplotype study on C4 polymorphism in Japanese: associations with MHC alleles complotypes and HLA complement haplotypes. Immunogenetics 22:359–364
Tokunaga K, Saueracker G, Kay PH, Christiansen FT, Anand R, Dawkins RL (1988) Extensive deletions and insertions in different MHC supratypes detected by pulsed field gel electrophoresis. J Exp Med 168:933–940
Tokunaga K, Kay PH, Christiansen FT, Saueracker G, Dawkins RL (1989) Comparative mapping of the human major histocompatibility complex in different racial groups by pulsed field gel electrophoresis. Hum Immunol 26:99–106
Tsuji K, Inouye H, Nose Y, Sasazuki T, Ozawa A, Ohkido M (1979) Further study on HLA-A, B, C, D, DR and haplotype antigen frequencies in psoriasis vulgaris. Acta Derm Venereol (Stockh) 87 [Suppl]:107–108
WHO-HLA Nomenclature Committee (1988) Nomenclature for factors of the HLA system. Vox Sang 55:119–126
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Nakagawa, H., Akazaki, S., Asahina, A. et al. Study of HLA class I, class II and complement genes (C2, C4A, C4B and BF) in Japanese psoriatics and analysis of a newly-found high-risk haplotype by pulsed field gel electrophoresis. Arch Dermatol Res 283, 281–284 (1991). https://doi.org/10.1007/BF00376613
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DOI: https://doi.org/10.1007/BF00376613