Summary
The phenotype of rotund (rn) null alleles is described, and compared to wild type. The mutants are expressed zygotically and cause position specific defects in certain imaginal discs (antenna, legs, wing, haltere and proboscis) and their corresponding adult derivatives. In the discs, specific folds are absent in rn mutants compared to wild type. Clonal analysis shows that the rn + gene is partially autonomous in its expression in cells destined to form certain distal parts of the adult appendages. The results are consistent with the idea that the rn + gene is required for normal morphogenesis of specific distal parts of the adult appendages.
Similar content being viewed by others
References
Anderson KV, Jürgens G, Nüsslein-Volhard C (1985) Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product. Cell 42:779–789
Bryant PJ (1978) Pattern formation in imaginal discs. In: Ashburner M, Wright TRF (eds) The genetics and biology of Drosophila, vol 2c. Academic Press, London, pp 230–235
Bryant PJ, Girton JR, Martin P (1980) Physical and pattern continuity in the insect epidermis. In: Locke M., Smith DS (eds) Insect biology in the future. Academic Press, New-York, pp 517–542
Cavener DR, Ottsen DC, Kaufman TC (1986) A rehabilitation of the genetic map of the 84BD region in Drosophila melanogaster. Genetics 114:111–123
Crick FHC, Lawrence PA (1975) Compartments and polyclones in insect development. Science 189:340–347
Duncan IW, Kaufman TC (1975) Cytogenetic analysis of chromosome 3 in Drosophila melanogaster. Mapping of the proximal portion of the right arm. Genetics 80:733–752
Ferris GF (1950) External morphology of the adult. In: Demerec M (ed) Biology of Drosophila. J. Wiley, New York, pp 268–418
Friström D (1968) Cellular degeneration in wing development of the mutant vestigial of Drosophila melanogaster. J Cell Biol 39:488–491
Friström D (1969) Cellular degeneration in the production of some mutant phenotypes in Drosophila melanogaster. Mol Gen Genet 103:363–379
Friström D, Friström JW (1975) The mechanism of evagination of imaginal discs of Drosophila melanogaster. I. General considerations. Dev Biol 43:1–23
Garcia-Bellido A, Ripoll P, Morata G (1973) Developmental compartmentalisation of the wing disc of Drosophila. Nature 245:251–253
Held LI Jr, Duarte CM, Derakshanian K (1986) Extra tarsal joints and abnormal cuticular polarities in various mutants of Drosophila melanogaster. Wilhelm Roux's Arch 195:145–157
Ingham PW, Howard KR, Ish-Horowicz D (1985) Transcription pattern of the Drosophila segmentation gene hairy. Nature 318:439–445
King RC (1970) Ovarian development in Drosophila melanogaster. Academic Press, New York
Lawrence PA (1973) The development of spatial patterns in the integument of insects. In: Counce SJ, Waddington CH (eds) Development systems: insects. Academic Press, New York, pp 157–209
Lawrence PA (1981) The cellular basis of segmentation in insects. Cell 26:3–10
Lawrence PA, Morata G (1976) Compartments in the wing of Drosophila: A study of the engrailed gene. Dev Biol 50:321–337
Lawrence PA, Morata G (1979) Early development of thoracic discs of Drosophila. Wilhelm Roux's Arch 187:375–379
Lawrence PA, Struhl G, Morata G (1979) Bristle patterns and compartment boundaries in the tarsi of Drosophila. J Embryol Exp Morphol 51:195–208
Lewis EB (1978) A gene complex controlling segmentation in Drosophila. Nature 276:565–570
Lindsley DL, Grell EH (1968) Genetic variations of Drosophila melanogaster. Carnegie Institute Washington Publication 627
Morata G, Ropoll P (1975) Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev Biol 42:211–221
Nüsslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287:795–801
O'Brochta D, Bryant PJ (1983) Cell degeneration and elimination in the imaginal wing disc, caused by the mutations vestigial and ultravestigial of Drosophila melanogaster. Wilhelm Roux's Arch 192:285–294
Schubiger G (1968) Anlageplan, Determinationszustand und Transdeterminationsleistungen der männlichen Vorbeinscheibe von Drosophila melanogaster. Wilhelm Roux's Arch Entw Mech Org 160:9–40
Sedlak BJ, Manzo R, Stevens M (1984) Localized cell death in Drosophila imaginal wing disc epithelium caused by the mutation apterous-blot. Dev Biol 104:489–496
Steiner E (1976) Establishment of compartments in the developing leg imaginal discs of Drosophila melanogaster. Wilhelm Roux's Arch 180:9–30
Tokunaga C, Gerhart JC (1976) The effect of growth and joint formation on bristle pattern in D. melanogaster. J Exp Zool 198:79–95
Wakimoto BT, Kaufman TC (1981) Analysis of larval segmentation in lethal genotypes associated with the Antennapedia gene complex (ANT-C) in Drosophila melanogaster. Dev Biol 81:51–64
Wieschaus E, Gehring WJ (1976) Clonal analysis of primordial disc cells in the early embryo of Drosophila melanogaster. Dev Biol 50:249–263
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kerridge, S., Thomas-Cavallin, M. Appendage morphogenesis in Drosophila: a developmental study of the rotund (rn) gene. Roux's Arch Dev Biol 197, 19–26 (1988). https://doi.org/10.1007/BF00376037
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00376037