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Pflügers Archiv

, Volume 423, Issue 3–4, pp 202–205 | Cite as

Involvement of K+ channels in the quercetin-induced inhibition of neuroblastoma cell growth

  • Béatrice Rouzaire-Dubois
  • Valérie Gérard
  • Jean -Marc Dubois
Excitable Tissues and Central Nervous Physiology

Abstract

The effects of the flavonoid quercetin on cell proliferation and voltage-dependent K+ current were studied on mouse neuroblastoma×glioma hybrid cells. In the presence of 1 % fetal calf serum, quercetin inhibited both cell proliferation and K+ current with effective doses inducing half-maximum effects of 10 μM and 70 μM respectively. Valinomycin (1 nM) antagonized 80 % of the growth-inhibitory effects of 10 μM quercetin. The results suggest that at least a part of the antiproliferative effect of quercetin is mediated by a K+ channel blockade. They further confirm a role for K+ channels in mitogenesis and cell proliferation.

Key words

Potassium channels Neuroblastoma cells Quercetin Cell proliferation 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Béatrice Rouzaire-Dubois
    • 1
  • Valérie Gérard
    • 1
  • Jean -Marc Dubois
    • 1
  1. 1.Laboratoire de Physiologie Cellulaire, URA CNRS 1121, bât. 443Université Paris-SudOrsay CedexFrance

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