Abstract
The histological similarities of seborrhoeic keratoses and common warts led to the investigation of the possible occurrence of human papillomavirus DNA (HPV-DNA) in a large number of nongenital seborrhoeic keratoses using the in situ hybridization technique. All specimens derived from normal skin (n=173) were negative for the applied HPV-DNA probe, whereas the HPV genome was detected in 34 of 173 seborrhoeic keratosis specimens (19.65%). Of 34 HPV-positive specimens, 15 contained types 6/11 and 14 types 31/33/35, and 5 showed no positive reaction to the applied types. These results suggest that a considerable percentage of nongenital seborrhoeic keratoses may be related to an HPV infection.
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References
Arends MJ, Wyllie AH, Bird CC (1990) Papillomaviruses and human cancer. Hum Pathol 21: 686–698
Baer RL, Garcia RL, Partsalidou V, Ackerman AB (1981) Papillated squamous cell carcinoma in situ arising in a seborrheic keratosis. J Am Acad Dermatol 5: 561–564
Eliezri YD, Silverstein SJ, Nuovo GJ (1990) Occurrence of human papillomavirus type 16 DNA in cutaneous squamous and basal cell neoplasms. J Am Acad Dermatol 23: 836–842
Kawashima M, Favre M, Obalek S, Jablonska S, Orth G (1990) Premalignant lesions and cancers of the skin in the general population: evaluation of the role of human papillomaviruses. J Invest Dermatol 95: 537–542
Kwittken J (1974) Malignant changes in seborrheic keratoses. Mt Sinai J Med 41: 792–801
Leonardi CL, Zhu W-Y, Kinsey WH, Penneys NS (1991) Seborrheic keratoses from the genital region may contain human papillomavirus DNA. Arch Dermatol 127: 1203–1206
Mackie RM (1992) Epidermal skin tumours. In: Champion RH, Burton JL, Ebling FJG (eds) Textbook of dermatology. Black-well, London, pp 1465–1467
McFadden N, Hande KO (1989) A survey of elderly new patients at a dermatology outpatient clinic. Acta Derm Venereol (Stockh) 69: 260–262
McKee PH (1990) Seborrheic keratoses. In: McKee PH (ed) Pathology of the skin. Lippincott, Philadelphia, pp 1424–1426
Monteaqudo JC, Jorda E, Terencio C, Llombart-Bosch A (1989) Squamous cell carcinoma in situ (Bowen's disease) arising in seborrheic keratosis: three lesions in two patients. J Cutan Pathol 16: 348–352
Obalek S, Jablonska S, Baudenon S, Walczak L, Orth G (1986) Bowenoid papulosis of the male and female genitalia: risk of cervical neoplasia. J Am Acad Dermatol 14: 433–444
Pfister H, Fuchs PG (1987) Papillomaviruses: particles, genome organisation and proteins. In: Syrjanen K, Gissmann L, Koss LG (eds) Pappillomaviruses and human disease. Springer, New York Berlin Heidelberg, pp 1–18
Quan MB, Moy RL (1991) The role of human papillomavirus in carcinoma. J Am Acad Dermatol 25: 698–705
Rahbari H (1979) Bowenoid transformation of seborrheic verrucae (keratoses). Br J Dermatol 101: 459–463
Roberts S, Ashmole I, Johnson GD, Kreder JW, Gallimore PH (1993) Cutaneous and mucosal human papillomavirus E4 proteins form intermediate filament-like structures in epithelial cells. Virology 197: 176–187
Rundlinger R, Grob R, Yu YX, Schnyder VW (1989) Human papillomavirus-35-positive bowenoid papulosis of the anogenital area and concurrent human papillomavirus-35-positive verruca with bowenoid dysplasia of the periungual area. Arch Dermatol 125: 655–659
Sanderson KV (1968) The structure of seborrheic keratoses. Br J Dermatol 80: 588–593
Soler C, Chardonnet Y, Euvrard S, Chignol MC, Thivolet J (1992) Evaluation of human papillomavirus type 5 on frozen sections of multiple lesions from transplant recipients with in situ hybridization and non-isotopic probes. Dermatology 184: 248–253
Stone MS, Nooman CA, Tschen J, Bruce S (1987) Bowen's disease of the feet. Presence of human papillomavirus 16 DNA in tumor tissue. Arch Dermatol 123: 1517–1520
Zhao Y, Lin Y, Luo R, Huang X, Liu M, Xia M, Jin H (1989) Human papillomavirus (HPV) infection in seborrheic keratosis. Am J Dermatopathol 11: 209–212
Zhu W-Y, Leonardi C, Kinsey W, Penneys NS (1991) Irritated seborrheic keratoses and benign verrucous acanthomas do not contain papillomavirus DNA. J Cutan Pathol 18: 449–452
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Dedicated to Professor Dr. H. Ippen on the occasion of his 70th birthday
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Tsambaos, D., Monastirli, A., Kapranos, N. et al. Detection of human papillomavirus DNA in nongenital seborrhoeic keratoses. Arch Dermatol Res 287, 612–615 (1995). https://doi.org/10.1007/BF00374085
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DOI: https://doi.org/10.1007/BF00374085