Summary
Infusion of glutamine (2 μmol/min) into the superior mesenteric vein leads to a decrease of renal glomerular filtration rate (GFR) and urinary flow rate (V), whereas infusion of identical amounts of glutamine into the jugular vein does not significantly alter GFR or V. The effect of mesenteric glutamine is mimicked by mesenteric infusion of 5 nmol/min serotonin and is abolished in the presence of 20 nmol/min methysergide. The effect of mesenteric serotonin is almost abolished after transection of vagal hepatic nerves. The observations point to a serotoninergic hepatorenal reflex regulating renal function.
References
Andrews WHH, Orbach J. A study of compounds which initiate and block nerve impulses in the perfused rabbit liver. Br. J. Pharmacol. 1973; 49:192–204
Davidson EW, Dunn MJ. Pathogenesis of the hepatorenal syndrome. Ann Rev Med 1987;38:361–372.
DiBona GF. Update on renal neurology: Role of the renal nerves in formation of edema. Mayo Clin Proc 1989, 64:469–472.
DiBona GF, Sawin LL. Role of renal nerves in sodium retention of cirrhosis and congestive heart failure. Am J Physiol 1991; in press.
Führ J, Kaczmarczyk J, Krüttgen CD. Eine einfache colorimetrische Methode zur Inulinbestimmung für Nieren-clearance-Untersuchungen bei Stoffwechselgesunden und Diabetikern. Klin Wschr 1955;33:729–730.
Häussinger D, Lang F, Bauers K, Gerok W. Interactions between glutamine metabolism and cell volume regulation in perfused rat liver. Eur. J. Biochem 1990;188: 689–695.
Kostreva DR, Castaner A, Kampine JP. Reflex effects of hepatic baroreceptors on renal and cardiac sympathetic nerve activity. Am J Physiol 1980;238:R390-R394.
Lang F, Tschernko E, Öttl I, Schulze E, Hallbrucker C, Häussinger D. Hepatic regulation of renal function. J Am Soc Nephrol 1990;1:667.
Levy M, Wexler MJ. Sodium excretion in dogs with low-grade caval constriction: Role of hepatic nerves. Am J Physiol 1987;253:F672-F678.
Solis-Herruzo JA, Duran A, Favela V, Castellano G, Madrid JL, Munoz-Yagüe MT, Morillas JD, Estenoz J. Effects of lumbar sympathetic block on kidney function incirrhotic patients with hepatorenal syndrome. J of Hepatology 1987;5:167–173.
Veelken R, Sawin L, Luft FC, DiBona GF. Die sympathische Nierennervaktivität (RNA) steht unter der Kontrolle serotonerger (5-HT3) kardiorenaler Reflexe. Dustri-Verlag Sonderheft, 1990;9:421.
Welbourne TC, Childress D, Givens G. Renal regulation of interorgan glutamine flow in metabolic acidosis. Am J Physiol 1986;251:R858-R866.
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Lang, F., Öttl, I., Freudenschuß, K. et al. Serotoninergic hepatorenal reflex regulating renal glomerular filtration rate. Pflügers Arch. 419, 111–113 (1991). https://doi.org/10.1007/BF00373755
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DOI: https://doi.org/10.1007/BF00373755