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Screening of potent inhibitors of collagen synthesis in cultured human skin fibroblasts

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References

  1. Krieg T, Perlish JS, Mauch C, Fleischmajer R (1985) Collagen synthesis by scleroderma fibroblasts. Ann NY Acad Sci USA 460: 375–386

    Google Scholar 

  2. Raghow R, Postlethwaite AE, Keski-Oja J, Moses HL, Kang AH (1987) Transforming growth factor-β increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts. J Clin Invest 79: 1285–1288

    Google Scholar 

  3. Kurata S, Hata R (1991) Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative. J Biol Chem 266: 9997–10003

    Google Scholar 

  4. Kahari VM, Heino J, Vuorio E (1987) Interleukin-I increases collagen production and mRNA levels in cultured skin fibroblasts. Biochim Biophys Acta 929: 142–147

    Google Scholar 

  5. Solis-Herruzo JA, Brenner DA, Chojkier M (1988) Tumor necrosis factor α inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. J Biol Chem 263: 5841–4845

    Google Scholar 

  6. Jimenez SA, Freundlich B, Rosenbloom J (1984) Selective inhibition of human diploid fibroblast collagen synthesis by interferons. J Clin Invest 74: 1112–1119

    Google Scholar 

  7. Peterkofsky B, Diegelmann R (1971) Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins. Biochemistry 10: 988–994

    Google Scholar 

  8. Whitman HH, Case DB, Laragh JH, Christian CL, Botstein G, Marica H, LeRoy CE (1982) Variable response to oral angiotensin-converting enzyme blockade in hypertensive scleroderma patients. Arthritis Rheum 25: 241–248

    Google Scholar 

  9. Pettinager WA, Mitchell HC (1973) Minoxidil — an alternative to nephrectomy for refractory hypertension. New Engl J Med 289: 167–173

    Google Scholar 

  10. Murad S, Pinnell SR (1987) Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil. J Biol Chem 262: 11973–11978

    Google Scholar 

  11. Koda A, Kursahima Y, Nakazawa M (1985) The inhibition mechanism of histamine release by N-(3,4-dimethoxycinnamoyl) anthranilic acid. Int Arch Allergy Appl Immunol 77: 244–245

    Google Scholar 

  12. Isaji M, Nakajoh M, Naito J (1987) Selective inhibition of collagen accumulation by N-(3,4-dimethoxycinnamoyl) anthranilic acid (N-5') in granulation tissue. Biochem Pharmacol 36: 469–474

    Google Scholar 

  13. Chung HY, Yokozawa Z, Oura H (1986) Effect of extract from Salviae miltiorrhizae radix on uremic rats. Chem Pharm Bull 34: 3818–3822

    Google Scholar 

  14. Chvapil M (1982) Experimental modification of collagen synthesis and degradation and their therapeutic applications. In: Weiss JB, Jayson MIV (eds) Collagen in health and disease. Churchill Livingston, New York, pp 206–217

    Google Scholar 

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Yamada, H., Shigematsu, T., Tajima, S. et al. Screening of potent inhibitors of collagen synthesis in cultured human skin fibroblasts. Arch Dermatol Res 287, 506–508 (1995). https://doi.org/10.1007/BF00373438

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  • DOI: https://doi.org/10.1007/BF00373438

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