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Tests of association of immunoglobulin allotype genes and viral oncogenesis in chickens

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Abstract

Chickens from Regional Poultry Research Laboratory (RPRL) inbred line 63 are resistant to virally-induced Marek's disease (MD) and lymphoid leukosis (LL) and are relatively strong regressors of virally-induced Rous sarcomas. In contrast, RPRL line 100 chickens are highly susceptible to MD and LL and are weaker regressors of Rous sarcomas than line 63. RPRL lines 100 and 63 differ for alleles at the IgG-1 (G-1) allotype locus, but have identical IgM-1 (M-1) allotype alleles. To test the possible association of the G-1 locus with variations in resistance to virally-induced tumors, homozygous and heterozygous genotypes among F3 crosses were infected. F3 chickens with different G-1 types were comparable in their resistance to MD tumors following inoculation with the JM strain of the MD virus, and for their ability to regress Rous sarcoma tumors induced by the Rous sarcoma virus (RSV) RAV-1. However, following RAV-1 virus infection a smaller proportion of G-1 a/G-1 a F3 or F4 birds developed LL tumors than G-1 a/G-1 e and G-1 e/G-1 e birds. Genes determining immunoglobulin heavy chains were therefore associated with a recessive resistance to B-cell lymphomagenesis in chickens.

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Authors and Affiliations

  1. U.S. Department of Agriculture, Agricultural Research Service, Regional Poultry Research Laboratory, 3606 East Mount Hope Road, 48823, East Lansing, Michigan

    Larry D. Bacon, Aly M. Fadly, Richard L. Witter & Lyman B. Crittenden

  2. Department of Microbiology, University of Hawaii, 96822, Honolulu, Hawaii

    Lean Kuan Ch'ng, John Spencer & Albert A. Benedict

Authors
  1. Larry D. Bacon
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  2. Lean Kuan Ch'ng
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  3. John Spencer
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  4. Albert A. Benedict
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  5. Aly M. Fadly
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  6. Richard L. Witter
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  7. Lyman B. Crittenden
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Bacon, L.D., Ch'ng, L.K., Spencer, J. et al. Tests of association of immunoglobulin allotype genes and viral oncogenesis in chickens. Immunogenetics 23, 213–220 (1986). https://doi.org/10.1007/BF00373015

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  • DOI: https://doi.org/10.1007/BF00373015

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