Archives of Toxicology

, Volume 35, Issue 2, pp 91–96 | Cite as

The subacute and chronic toxicity of cetyltrimethylammonium bromide (CTAB), a cationic surfactant, in the rat

  • B. Isomaa
  • J. Reuter
  • B. M. Djupsund
Original Investigations


Cetyltrimethylammonium bromide (CTAB), a cationic surfactant, was given to male and female Sprague-Dawley rats in drinking water in dosages of approximately 10, 20, and 45 mg/kg/day for 1 year. The surfactant was well tolerated at the two lowest dose levels. At the highest dose level a reduction in body weight was observed. In males the body weight remained reduced throughout the study, but in females the body weight was reduced only during the first 2 months of the study. It was found that food conversion was less efficient in male rats during the first 7 weeks of the study. No compound-related gross pathologic changes were seen on autopsy and no microscopic alterations were found in the wall of stomach and small intestine of treated animals.

Key words

Cetyltrimethylammonium bromide Detergent Surfactant Chronic toxicity 


Cetyltrimetylammoniumbromid (CTAB), ein kationaktives Tensid, wurde bei männlichen und weiblichen Sprague-Dawley-Ratten im Trinkwasser in Dosen von ca. 10, 20 und 45 mg/kg/Tag während eines Jahres appliziert. Die Tenside wurden bei den zwei niedrigsten Dosen gut toleriert. Bei der höchsten Dosis wurde eine Abnahme des Körpergewichts festgestellt. Bei den Männchen verblieb das Körpergewicht während der ganzen Untersuchung reduziert, bei den Weibchen dagegen war das Körpergewicht nur während der 2 ersten Monate der Untersuchung reduziert. Es wurde beobachtet, daß die Nahrungsverwertung bei den männlichen Ratten weniger effektiv in den 7 ersten Wochen der Untersuchung war. Keine verbindungsbedingten groben pathologischen Veränderungen wurden bei der Obduktion gesehen und keine mikroskopischen Veränderungen wurden in den Wänden des Magens und des Dünndarmes der applizierten Tiere gefunden


Cetyltrimetylammoniumbromid Waschmittel Tenside Chronische Toxicität 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • B. Isomaa
    • 1
  • J. Reuter
    • 1
  • B. M. Djupsund
    • 1
  1. 1.Institute of BiologyÅbo AkademiÅbo 50Finland

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