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A data reduction technique for describing and quantifying detrusor instability

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Abstract

Urodynamic studies obtained from 1151 patients with detrusor instability or detrusor hyperreflexia were analyzed to calculate the total impulse of unstable forces generated by the detrusor. A regression equation was also calculated from the recordings of detrusor pressure and time obtained during the filling study. These data were entered into a principal components analysis to obtain two linear reduction models, which described 65% of the variance measured. These two models were found to be useful in achieving quantitative and qualitative descriptions of detrusor instability. Differences in the patterns of detrusor activity were found between the sexes (p<0.001); between age groups in women (p<0.001), but of less clinical significance in men (p=0.021); between women with differing symptoms (p=0.002) and pathological states (p<0.001); and between patients with differing voiding efficiency (p<0.001). Differences in the patterns of detrusor hyperreflexia when compared to detrusor instability were also found (p<0.001).

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Malone-Lee, J., Orugun, O. A data reduction technique for describing and quantifying detrusor instability. Int Urogynecol J 4, 204–211 (1993). https://doi.org/10.1007/BF00372340

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