Abstract
Urodynamic studies obtained from 1151 patients with detrusor instability or detrusor hyperreflexia were analyzed to calculate the total impulse of unstable forces generated by the detrusor. A regression equation was also calculated from the recordings of detrusor pressure and time obtained during the filling study. These data were entered into a principal components analysis to obtain two linear reduction models, which described 65% of the variance measured. These two models were found to be useful in achieving quantitative and qualitative descriptions of detrusor instability. Differences in the patterns of detrusor activity were found between the sexes (p<0.001); between age groups in women (p<0.001), but of less clinical significance in men (p=0.021); between women with differing symptoms (p=0.002) and pathological states (p<0.001); and between patients with differing voiding efficiency (p<0.001). Differences in the patterns of detrusor hyperreflexia when compared to detrusor instability were also found (p<0.001).
Similar content being viewed by others
References
Malone-Lee JG. New discoveries in lower urinary tract dysfunction in the elderly. Rev Clin Gerontol 1992; 2:45–61
International Continence Society. First report on standardization of terminology of lower urinary tract function. Br J Urol 1976; 48:39–42
International Continence Society. Standardization of terminology of lower urinary tract function. Neurourol Urodyn 1988; 7:403–426
Malone-Lee JG. The pharmacology of urinary incontinence. In: Barbagallo-Sangiorgi G, Exton-Smith AN, eds. Aging and Drug Therapy. London: Plenum, 1983;419–440
Gerstenberg TC, Klarskov P, Ramirez D, Hald T. Terodilane in the treatment of women with urgency and motor urge incontinence. A clinical and urodynamic double-blind cross-over study. Br J Urol 1986; 58:129–133
Primus G, Pummer K. Oxybutynin hydrochloride in the management of detrusor instability. Int J Urol Nephrol 1990; 22:243–248
van Waalwijk, van Doorn ES, Zwiers W. Ambulant monitoring to assess the efficiacy of oxybutynin chloride in patients with mixed incontinence. Eur Urol 1990; 18:49–51
Griffiths DJ. Assessment of detrusor contraction strength or contractility. Neurourol Urodyn 1991; 10:1–18
Chapple CR, Malone-Lee JG. A new comprehensive microcomputer program for the urodynamics unit. Eur Urol 1990; 18:33–36
Manly BFJ. Principal components analysis. In: Manly BFJ, ed. Multivariate statistical analysis. Chapman and Hall, 1990;59–71
Armitage P, Berry G. Multivariate methods. In: Armitage P, Berry G, eds. Statistical methods in medical research. London: Blackwell Scientific Publications, 1987;326–33
Cruze E, Hartzell B. Minitab references manual. Rosemont: Quickset inc., 1991
Massey BS. Measures in sciences and engineering. Chichester: John Wiley and Sons, 1986;55–58
Fenn WO, Marsh BS. Muscular force at different speeds of shortening. J Physiol 1935; 85:277–297
Hill AV. The strength-duration relation for electric excitation of medullated nerve. Proc Roy Soc Lond 1936; 119:440–453
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Malone-Lee, J., Orugun, O. A data reduction technique for describing and quantifying detrusor instability. Int Urogynecol J 4, 204–211 (1993). https://doi.org/10.1007/BF00372340
Issue Date:
DOI: https://doi.org/10.1007/BF00372340