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H-2 S region determined polymorphic variants of the C4, Slp, C2, and B complement proteins: A compilation

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References

  • Alper, C. A.: In Martin E. Dorf (ed.): The Role of the Major Histocompatibility Complex in Immunobiology, pp. 173–220, Garland STPM Press, New York, 1981

    Google Scholar 

  • Atkinson, J. P., McGinnis, K., Brown, L., Peterein, J., and Shreffler, D.: A murine C4 molecule with reduced hemolytic efficiency. J. Exp. Med. 151: 492–497, 1980a

    Google Scholar 

  • Atkinson, J. P., McGinnis, K., and Shreffler, D.: Development and characterization of a hemolytic assay for mouse C4. J. Immunol. Methods 33: 351–368, 1980b

    Google Scholar 

  • Bentley, C., Bitter-Suerman, D., Hadding, U., and Brade, V.: In vitro synthesis of Factor B of the alternate pathway of complement activation by mouse peritoneal macrophages. Eur. J. Immunol. 6: 393–398, 1976

    Google Scholar 

  • Brown, L. J. and Shreffler, D. C.: Female expression of the H-2-linked sex-limited protein (Slp) due to non-H-2 genes. Immunogenetics 10: 19–24, 1980

    Google Scholar 

  • Carroll, M. C. and Capra, J. D.: Studies on murine Ss protein: Demonstration that Ss protein is functionally the fourth component of complement. Proc. Natl. Acad. Sci. U.S.A. 75: 2424–2428, 1978

    Google Scholar 

  • Carroll, M. C. and Capra, J. D.: Studies on murine Ss protein: Demonstration that S locus encodes structural gene for fourth component of complement. Proc. Natl. Acad. Sci. U.S.A. 76: 4641–4645, 1979

    Google Scholar 

  • Chan, A. C., Mitchell, K. R., Munns, T. W., Karp, D. R., and Atkinson, J. P.: Identification and partial characterization of a novel form of the fourth component of human complement: Evidence that the secreted form is different from the major plasma form. Proc. Natl. Acad. Sci. U.S.A., in press, 1982

  • Chu, V.F.H., Marsh, L., and Gigli, I.: Chido and Rodgers antigenic determinant on the fourth component of human complement. J. Immunol. 128: 181–185, 1982

    Google Scholar 

  • Ferreira, A., Nussenzweig, V., and Gigli, I.: Structural and functional differences between the H-2 controlled Ss and Slp proteins. J. Exp. Med. 148: 1186–1197, 1978

    Google Scholar 

  • Ferreira, A., David, C. S., and Nussenzweig, V.: The murine H-2.7 specificity is an antigenic determinant of C4d, a fragment of the fourth component of the complement system. J. Exp. Med. 151: 1424–1435, 1980a

    Google Scholar 

  • Ferreira, A., Michaelson, J., and Nussenzweig, V.: A polymorphism of the γ-chain of mouse C4 controlled by the S region of the major histocompatibility complex. J. Immunol. 125: 1178–1182, 1980b

    Google Scholar 

  • Ferreira, A., Michaelson, J., and Nussenzweig, V.: H-2 controlled polymorphism of the γ-chain of SIp (sex-limited protein). Immunogenetics 11: 491–497, 1980c

    Google Scholar 

  • Gigli, I., von Zabern, I., and Porter, R. P.: The isolation and structure of C4, the fourth component of human complement. Biochem. J. 165: 439–446, 1977

    Google Scholar 

  • Goldberger, G. and Colten, H. R.: Precursor complement protein (pro-C4) is converted in vitro to native C4 by plasmin. Nature 286: 514–516, 1980

    Google Scholar 

  • Goldberger, G., Abraham, G. N., Williams, J., and Colten, H. R.: NH2-terminal sequence analysis of proC4, the precursor of the fourth component of guinea pig complement. J. Biol. Chem. 255: 7071–7074, 1980

    Google Scholar 

  • Gorman, J. C., Jackson, R., DeSantola, J. R., Shreffler, D., and Atkinson, J. P.: Development of a hemolytic assay for mouse C2 and determination of its genetic control. J. Immunol. 125: 344–351, 1980

    Google Scholar 

  • Harrison, R. A., Thomas, M. L., and Tack, B. F.: Sequence determination of the thiolester site of the fourth component of human complement. Proc. Natl. Acad. Sci. U.S.A. 78: 7388–7392, 1981

    Google Scholar 

  • Huang, C. M. and Klein, J.: Murine antigen H-2.7: localization of its antigenic determinant to the Ss (C4) molecule. Immunogenetics 11: 605–615, 1980

    Google Scholar 

  • Karp, D. R. and Shreffler, D.: S region genetic control of murine C4 biosynthesis: Analysis of pro-C4 cleavage. Immunogenetics 16: 171–176, 1982

    Google Scholar 

  • Karp, D. R., Parker, K. L., Shreffler, D. C., and Capra, J. D.: Characterization of the murine C4 precursor (Pro-C4): Evidence that the carboxy-terminal subunit is the C4 γ-chain. J. Immunol. 126: 2060–2062, 1981a

    Google Scholar 

  • Karp, D. R., Shreffler, D. C., and Atkinson, J. P.: Comparison of in vitro-synthesized and plasma derived forms of murine C4. Fed. Proc. 40: 1066, 1981b

    Google Scholar 

  • Karp, D. R., Shreffler, D. C., and Atkinson, J. P.: Characterization of the Mr difference between secreted C4 and the major form of C4 in murine plasma: Carboxy-terminal cleavage of the α-chain. Proc. Natl. Acad. Sci. U.S.A., in press, 1982a

  • Karp, D. R., Atkinson, J. P., and Shreffler, D. C.: Genetic variation in glycosylation of the fourth component of murine complement: Association with hemolytic activity. J. Biol. Chem. 257: 7330–7335, 1982b

    Google Scholar 

  • Karp, D. R., Capra, J. D., Atkinson, J. P., and Shreffler, D. C.: Structural and functional characterization of an incompletely processed form of murine C4 and Slp. J. Immunol. 128: 2336–2341, 1982c

    Google Scholar 

  • Karp, D. R., Parker, K. L., Shreffler, D. C., Slaughter, C., and Capra, J. D.: Amino acid sequence homologies and glycosylation differences between the fourth component of murine complement and sex-limited protein. Proc. Natl. Acad. Sci. U.S.A. 79: 6347–6349, 1982d

    Google Scholar 

  • Kawamoto, Y., Ueda, M., Ichikawa, H., and Miyama, A.: Complement proteins and macrophages. I. Quantitative estimation of Factor B produced by mouse peritoneal macrophages. Microbiol. Immunol. 23: 987–995, 1979

    Google Scholar 

  • Law, S. K. and Levine, R. P.: Interaction between the third complement protein and cell surface macromolecules. Proc. Natl. Acad. Sci. U.S.A. 74: 2701–2706, 1977

    Google Scholar 

  • Law, S. K., Lichtenberg, N. A., and Levine, R. P.: Covalent binding and hemolytic activity of complement proteins. Proc. Natl. Acad. Sci. U.S.A. 77: 7194–7198, 1980

    Google Scholar 

  • Parker, K. L., Capra, J. D., and Shreffler, D. C.: Partial amino acid sequences of the murine fourth component of complement (C4): Demonstration of homology with human C4 and identification of the amino-terminal subunit in Pro-C4. Proc. Natl. Acad. Sci. U.S.A. 77: 4275–4278, 1980

    Google Scholar 

  • Parker, K. L., Carroll, M. C., Shreffler, D. C., and Capra, J. D.: Identification of H-2 controlled structural variants of the murine Slp protein and demonstration of cis-regulation of its expression. J. Immunol. 126: 995–997, 1981

    Google Scholar 

  • Parker, K. L., Roos, M. H., and Shreffler, D. C.: Structural characterization of the murine fourth component of complement and sex-limited protein and their precursors: Evidence for two loci in the S region of the H-2 complex. Proc. Natl. Acad. Sci. U.S.A. 76: 5853–5857, 1979

    Google Scholar 

  • Paolucci, E. S. and Shreffler, D. C.: H-2-linked murine Factor B phenotypes. Immunogenetics, in press 1982

  • Passmore, H. C.: An erythrocyte and serum antigen with a specificity antithetical to the mouse C4 associated H-2.7 antigen. J. Immunol. 128: 2559–2562, 1982

    Google Scholar 

  • Roos, M. H. and Demant, P.: Murine complement Factor B sexual dimorphism and H-2 linked polymorphism. Immunogenetics 15: 23–32, 1982

    Google Scholar 

  • Roos, M. H., Atkinson, J. P., and Shreffler, D. C.: Molecular characterization of the Ss and Slp (C4) proteins of the mouse H-2 complex: Subunit composition, chain size polymorphism, and an intracellular (pro-Ss) precursor. J. Immunol. 121: 1106–1115, 1978

    Google Scholar 

  • Roos, M. H., Kornfeld, S., and Shreffler, D. C.: Characterization of the oligosaccharide units of the fourth component of complement (Ss protein) synthesized by murine macrophages. J. Immunol. 124: 2860–2863, 1980a

    Google Scholar 

  • Roos, M. H., Shreffler, D. C., and Kornfeld, S.: Role of glycosylation in the proteolytic processing and secretion of the 4th component of complement (Ss protein) of the mouse. J. Immunol. 125: 1869–1871, 1980b

    Google Scholar 

  • Natsuume-Sakai, S. N., Kaidoh, T., Nonaka, M., and Takahashi, M.: Structural polymorphism of murine C4 and its linkage to H-2. J. Immunol. 124: 2714–2720, 1980

    Google Scholar 

  • Shreffler, D. C.: The S region of the mouse major histocompatibility complex (H-2); genetic variation and funtional role in complement system. Transplant. Rev. 32: 140–167, 1976

    Google Scholar 

  • Shreffler, D. C.: Function, structure, and regulation of the murine C4/Slp protein variants. In W. Hildemann (ed.): Frontiers in Immunogenetics, pp. 107–120, Elsevier North Holland, Amsterdam 1981

    Google Scholar 

  • Shreffler, D. C., Atkinson, J. P., Brown, L. J., Parker, K. L., and Roos, M. H.: Genetics, structure and function of murine S region gene products. Proc. of the 7th International Convocation on Immunol. 17: 78–88, 1981

    Google Scholar 

  • Tack, B. F., Harrison, R. A., Janatova, J., Thomas, M. L., and Prahl, J. W.: Evidence for presence of an internal thiolester bond in third component of human complement. Proc. Natl. Acad. Sci. U.S.A. 77: 5764–5768, 1980

    Google Scholar 

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Authors and Affiliations

  1. The Howard Hughes Medical Institute Laboratories, Washington University School of Medicine, 63110, St. Louis, Missouri

    John P. Atkinson & Sara L. Newell

  2. Department of Medicine, Division of Rheumatology, and the James S. McDonnell Department of Genetics, Washington University School of Medicine, 63110, St. Louis, Missouri

    David R. Karp, Elaine P. Seeskin, Catherine C. Killion, Patricia A. Rosa & Donald C. Shreffler

Authors
  1. John P. Atkinson
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  2. David R. Karp
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  3. Elaine P. Seeskin
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  4. Catherine C. Killion
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  5. Patricia A. Rosa
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  6. Sara L. Newell
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  7. Donald C. Shreffler
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Atkinson, J.P., Karp, D.R., Seeskin, E.P. et al. H-2 S region determined polymorphic variants of the C4, Slp, C2, and B complement proteins: A compilation. Immunogenetics 16, 617–623 (1982). https://doi.org/10.1007/BF00372032

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  • DOI: https://doi.org/10.1007/BF00372032

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