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Assessment of some genetic non-MHC differences with GVHR-induced anti-listeria activity of macrophages

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Abstract

Parental cells A injected into (A × B)F1 heterozygotes induce a graftversus-host reaction (GVHR) which induces systemic activation of anti-Listeria-bactericidal capacity of host macrophages. When donor lymphocytes differ from parent A with respect to various non-H-2 genetic markers, they may or may not be able to induce a GVHR. Some, but not all, known and some unknown non-H-2 differences can be assessed by this method within nine to 12 days. The method is described and some of the following non-H-2 differences are shown to influence GVHR-induced macrophage activation: male H-Y antigen, H-3 or H-4 (but not H-1 or H-9), and as yet underlined differences that apparently exist between mouse substrains of the same or similar designation, but obtained from different breeding establishments.

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Abbreviations

H:

histocompatibility

GVHR:

graft-versus-host reaction

MHC:

major histocompatibility gene complex

SCRF:

Scripps Clinic and Research Foundation

J:

Jackson Laboratory

St:

Strong Foundation

Cum:

Cumberland View Farm

Ola:

Olac

Gh:

Dr. G. Haughton, Chapel Hill

Sal:

Dr. M. Cohn, La Jolla.

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Authors and Affiliations

  1. Institut für Pathologie, Abteilung für Experimentelle Pathologie, Universitätsspital, CH-8091, Zürich, Switzerland

    Rolf M. Zinkernagel & Alana Althage

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  1. Rolf M. Zinkernagel
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  2. Alana Althage
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Zinkernagel, R.M., Althage, A. Assessment of some genetic non-MHC differences with GVHR-induced anti-listeria activity of macrophages. Immunogenetics 16, 571–576 (1982). https://doi.org/10.1007/BF00372025

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  • DOI: https://doi.org/10.1007/BF00372025

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