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Pflügers Archiv

, Volume 419, Issue 6, pp 662–664 | Cite as

Intracellular calcium does not directly modulate cardiac pacemaker (if) channels

  • A. Zaza
  • G. Maccaferri
  • M. Mangoni
  • D. DiFrancesco
Short Communication Excitable Tissues and Central Nervous Physiology

Abstract

A study on the cardiac pacemaker current if in inside-out macro-patches of sino-atrial (SA) node cells has recently demonstrated that if channels are directly activated by intracellular cAMP [4]. Using the same preparation, here we investigate the possibility that internal Ca2+ ions play a role in the modulation of if channels. Our results indicate that Ca2+ ions do not have a direct activating effect on if.

Keywords

Calcium Human Physiology Intracellular Calcium Node Cell Intracellular cAMP 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • A. Zaza
    • 1
  • G. Maccaferri
    • 1
  • M. Mangoni
    • 1
  • D. DiFrancesco
    • 1
  1. 1.Dipartimento di Fisiologia e Biochimica Generali, ElettrofisiologiaUniversità di MilanoMilanoItaly

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