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Pflügers Archiv

, Volume 419, Issue 6, pp 610–615 | Cite as

Quantitative and sustained suppression of renal sympathetic nerve activity by left atrial distension in conscious dogs

  • Kenju Miki
  • Yoshiaki Hayashida
  • Keizo Shiraki
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology

Abstract

In order to investigate the interrelations between left atrial pressure (Pla) and renal sympathetic nerve activity (RSNA) and heart rate (HR), Pla was increased by a balloon both in conscious sham-operated and cardiac-denervated dogs. RSNA was decreased and HR was increased with increasing Pla in sham-operated dogs. The reflex changes in RSNA and HR induced by the stimulation of atrial receptors persisted for at least 15 min. There was a consistent relationship between Pla and RSNA which could be described by a single exponential equation: % Δ RSNA = 80.0(1−e−0.395 Δ Pla), or by a linear equation when ΔPla was less than 6 mmHg; %ΔRSNA=-13.5ΔPla−2.25. The relationship between Pla and HR can be described by a single exponential equation: Δ HR = 86.5(1−e−0.125 Δ Pla). A significant linear relationship between RSNA and HR was obtained during a graded left atrial distention (%ΔRSNA=-1.08ΔHR−17.7). In cardiac-denervated dogs, RSNA tended to increase and HR remained constant during the left atrial distention. These results indicate that left atrial receptors regulate RSNA and HR in both a quantitative and sustained manner in conscious sham-operated dogs.

Key words

Atrial mechanoreceptors Cardiac denervation Heart rate Body fluid regulation Conscious dog 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Kenju Miki
    • 1
  • Yoshiaki Hayashida
    • 1
  • Keizo Shiraki
    • 1
  1. 1.Departments of Physiology and Systems Physiology, School of MedicineUniversity of Occupational and Environmental HealthKitakyushuJapan

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