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Chemotherapy of bacterial plasmids

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Abstract

Pharmacological approaches to plasmid chemotherapy are: 1) discovery of novel antibacterial drugs against which plasmids do not carry resistance genes, 2) molecular modification of existing drugs to render them non-susceptible to plasmid-encoded enzymes, 3) development of drugs which are selective inhibitors of plasmid DNA replication, 4) development of drugs which inhibit phenotypic expression of plasmid genes, and 5) development of drugs which are inhibitors of drug-inactivating enzymes that are plasmid gene products.

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  1. Division of Communicable Disease and Immunology, Walter Reed Army Institute of Research, 20012, Washington, D.C., USA

    Fred E. Hahn

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  1. Fred E. Hahn
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Hahn, F.E. Chemotherapy of bacterial plasmids. Naturwissenschaften 66, 555–562 (1979). https://doi.org/10.1007/BF00368809

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