Abstract
Female mice of the H-2 k haplotype have been thought not to reject primary grafts of male skin. However, most BALB/c-H-2 k female mice bred in our colony rejected syngeneic male grafts. Graft rejection was sufficient to prime the mice for the subsequent generation of H-Y-specific cytotoxic T cells and delayed-type hypersensitivity responses.
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Ashman, R. B.: Male skin grafts induce tolerance in female CBA mice. Aust. J. Exp. Biol. Med. Sci. 60: 397–399, 1982
Ashman, R. B.: Some characteristics of the tolerance induced by male skin grafts in female CBA mice. Transplant. Proc., in press, 1983
Billingham, R. E. and Medawar, P. B.: A technique for free skin grafting in mammals. J. Exp. Biol. 28: 385–402, 1951
Brenan, M. and Müllbacher, A: Analysis of the cytotoxic T-cell response to H-Y in CBA/H mice. J. Immunol. 127: 681–685, 1981
Brenan, M., Simpson, E., and Müllbacher, A.: Analysis of haplotype preference in the cytotoxic T-cell response to H-Y. Immunogenetics 13: 133–146, 1981
Coons, J. A. and Goldberg, E. H.: Rejection of male skin by splenectomised female mice. Science 200: 320–321, 1978
Fierz, W., Brenan, M., Müllbacher, A., and Simpson, E.: Non-H-2 and H-2-linked immune response genes control the cytotoxic T-cell response to H-Y. Immunogenetics 15: 261–270, 1982
Gordon, R. D., Simpson, E., and Samuelson, L.: In vitro cell-mediated immune responses to the male-specific (H-Y) antigen in mice. J. Exp. Med. 142: 1108–1120, 1975
Müllbacher, A. and Brenan, M.: Cytotoxic T-cell response to H-Y in ‘non-responder’ CBA mice. Nature 285: 34–36, 1980
Pole, D. S. and Wedderburn, N.: Host-versus-graft responses to the H-Y antigen in mice. Transplantation 32: 165–167, 1981
Simpson, E.: The role of H-Y as a minor transplantation antigen. Immunol. Today 3: 97–106, 1982
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Ashman, R.B. Primary immune responses to H-Y in BALB/c-H-2 k mice. Immunogenetics 18, 125–129 (1983). https://doi.org/10.1007/BF00368540
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DOI: https://doi.org/10.1007/BF00368540