Abstract
Recombination has been detected for the first time between chromosome 6 loci controlling kappa chain expression in normal mouse serum immunoglobulin and the Lyt-3 locus. The recombination event occurred at the 26th or 27th backcross generation during the derivation of the Lyt-2 a, Lyt-3 a-congenic line B6.PL(85NS). The line is now homozygous for the Lyt-2 a, Lyt-3 a allele(s) at N30F13 and homozygous animals express the Igk-Ef1 b allele derived from C57BL/6. The frequency of recombination has been estimated to be 0.30% based on the present results and previous studies in which no recombination was detected. The results rule out the hypothesis that the Lyt-3 locus itself controls the light chain phenotype observed in normal serum immunoglobulin.
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Gibson, D.M., Maclean, S.J. & Cherry, M. Recombination between kappa chain genetic markers and the Lyt-3 locus. Immunogenetics 18, 111–116 (1983). https://doi.org/10.1007/BF00368538
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DOI: https://doi.org/10.1007/BF00368538