Abstract
Radionuclide imaging of benign soft-tissue tumors sometimes associated with extremity enlargement (7 patients) and/or osteodysplasia (6 patients) has demonstrated, in a total of 18 patients, several differentiating patterns of accumulation of Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA). Early imaging (within 15 min) as well as later imaging (one-half hour to 3 hours following the intravenous injection of the radiopharmaceutical) has shown that fatty tumors (lipomas, lipoblastomas, fibrofatty tissue) do not concentrate the isotope. Neurofibromas display gradual intensification of their radioactive content, while hemangiomas differ in their scintigraphic pattern depending on their histologic composition. Purely capillary hemangiomas have transient early intense activity while purely cavernous hemangiomas display no early activity but are well visualized on delayed scintigraphic images. Mixed hemangiomas display combined imaging characteristics of both capillary and cavernous types with the predominant pattern dependent upon the predominant histology. Aggressive fibromatosis exhibited an early fleeting display of intense radioactivity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ackland MK, Uhthoff HK (1986) Idiopathic localized gigantism: a 26-year follow-up. J Pediatr Orthop 6:618
Brooks B, Lehman RP (1924) The bone changes in Recklinghausen's neurofibromatosis. Surg Gynecol Obstet 38:587
Chung EB, Enzinger FM (1973) Benign lipoblastomasis. An analysis of 35 cases. Cancer 32:482
Enzinger FM, Weiss SW (1988) Soft tissue tumors. Mosby, St Louis, p 305
Front D, Royal HD, Israel O (1981) Scintigraphy of hepatic hemangiomas: the value of Tc-99m labeled red blood cells: Concise communication. J Nucl Med 22:684
Goldman AB, Kaye JJ (1977) Macrodystrophia lipomatosa: radiographic diagnosis. AJR 128:101
Gupta SR, Tuli SM, Srivastara TP (1985) Skeletal overgrowth with modeling error in neurofibromatosis. Clin Radiol 36:643
Hudson TM, Bertoni F, Enneking WF (1985) Scintigraphy of aggressive fibromatosis. Skeletal Radiol 13:643
Hudson TM, Vandrgriend RA, Springfield DS (1984) Aggressive fibromatosis: evaluation by computed tomography and angiography. Radiology 150:495
Kessler HB, Recht MP, Dalinka MK (1983) Vascular anomalies in association with osteodystrophies — a spectrum. Skeletal Radio 10:95
Lachman RS, Finkelstein J, Mehringer CM (1983): Macrodystrophia lipomatosa: radiographic diagnosis. Skeletal Radiol 9:248
Mandell GA, Dalinka MK, Coleman BG (1979) Fibrous lesions in the lower extremities in neurofibromatosis. AJR 133:1135
Mandell GA, Harcke HT, Davis N (1986) Accumulation of technetium-99m MDP in an intramuscular hemangioma. Clin Nucl Med 7:487
Mandell GA, Harcke HT, Sharkey C (1987) SPECT imaging of paraxial neurofibromatosis with Tc-99m DTPA. J Nucl Med 28:1688
Mandell GA, Herrick WC, Harcke HT (1985) Neurofibromas: location by scanning with Tc-99m DTPA. Work in Progress. Radiology 157:803
Mucke J, Willgerodt H, Kunzel R (1985) Variability in the Proteus syndrome: report of an affected child with progressive lipomatosis. Eur J Pediatr 143:143–320
Tibbles JAR, Cohen MM Jr (1986) Proteus syndrome: the Elephant Man diagnosis. Br Med J [Clin Res] 293:683
Wiedmann HR, Burgio GR, Aldenhoff P (1983) The Proteus syndrome: partial gigantism of the tumors, macrocephaly or other skull anomalies and possible accelerated growth and visceral affections. Eur J Pediatr 140:5
Yaghmai I, McKowne F, Alizadeh A (1976) Macrodactylia fibrolipomatosis. South Med J 69:1565
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mandell, G.A., Scott, C.I., Harcke, H.T. et al. Scintigraphic differentiation of congenital soft-tissue extremity enlargement with Tc-99m DTPA. Skeletal Radiol 18, 33–41 (1989). https://doi.org/10.1007/BF00366770
Issue Date:
DOI: https://doi.org/10.1007/BF00366770