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Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions

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Abstract

A group of 21 patients with malignant pleural effusions were treated with the instillation of 40 mg mitoxantrone intrapleurally, after complete fluid drainage. There was a 100% complete response rate with no toxic effects (0%). The mean survival of the patients was 57.1 weeks.

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References

  1. Adler RH, Carter D, Flassen KP (1976) Treatment of malignant pleural effusion: a method using tube thoracostomy and talo. Ann Thorac Surg 22: 8–15

    Google Scholar 

  2. Alberts DJ, Young L, Mason N, Salomon SE (1985) In vitro evaluation of anticancer drugs against ovarian cancer at a concentration achievable by intraperitoneal administration. Semin Oncol 2: 38–42

    Google Scholar 

  3. Bitran JD, Brown C, Desser RK, Kozloff MF, Shapiro C, Billings AA (1981) Intracavitary bleomycin for the control of malignant pleural effusions. J Surg Oncol 16: 273–277

    Google Scholar 

  4. Clamon GH (1992) Alkylating agents. In: Perry MC (ed) The chemotherapy source book. Williams & Wilkins, Baltimore, pp 286–300

    Google Scholar 

  5. Glover DJ, Grabelsky S, Glick JH (1993) Oncological emergencies and special complications. In: Calabresi P, Schein PS (eds) Medical oncology. McGraw-Hill, New York, pp 1020–1072

    Google Scholar 

  6. Groth G, Gatzemeir V, Haussingen V, et al (1991) Intrapleural palliative treatment of malignant pleural effusions with mitoxantrone versus placebo (pleural tube alone). Ann Oncol 23: 213–215

    Google Scholar 

  7. Hausheer FH, Yarbro JW (1985) Diagnosis and treatment of maligant pleural effusion. Semin Oncol 12: 54–75

    Google Scholar 

  8. Paladine W, Cunningham TJ, Sponzo R, et al (1976) Intracavitary bleomycin in the management of malignant effusions. Cancer 38: 1903–1905

    Google Scholar 

  9. Pass HJ (1989) Treatment of malignant pleural and pericardial effusions. In: De Vita VT, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology. Lippincott, Philadelphia, pp 2317–2327

    Google Scholar 

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Author notes

  1. Manuel Morales M. D., Ph. D.

    Present address: , P.O. Box 430, E-38080, La Laguna, Tenerife, Canary Islands, Spain

Authors and Affiliations

  1. Division of Medical Oncology, Department of Medicine, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Canary Islands, Spain

    Manuel Morales M. D., Ph. D. & Maria del Carmen Expósito M.D.

Authors
  1. Manuel Morales M. D., Ph. D.
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  2. Maria del Carmen Expósito M.D.
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Morales, M., Expósito, M.d.C. Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions. Support Care Cancer 3, 147–149 (1995). https://doi.org/10.1007/BF00365856

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  • DOI: https://doi.org/10.1007/BF00365856

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