Summary
Glutamic acid levels were investigated in the cerebrospinal fluid and blood serum of patients with schizophrenia, Huntington's chorea, and sciatic nerve compression by lumbar disc protrusion. In the serum the glutamic acid levels were equal in all three groups; in the cerebrospinal fluid (CSF) of schizophrenic and Huntington's patients, however, the glutamic acid was decreased to almost half that of the lumbar disc group which served as control. Most of the patients were treated with neuroleptic drugs. However, since in one case (the daughter of a Huntington's patient) the CSF glutamic acid was decreased although this woman had had no neuroleptic treatment, it seems more likely that the glutamic acid decrease is due to the disease rather than to the neuroleptic treatment.
Zusammenfassung
Im Liquor von drei Patienten-Gruppen mit Huntington-Chorea, Schizophrenie und Bandscheibenvorfällen wurde der Glutaminsäuregehalt bestimmt. Im Liquor der Huntington-Patienten und der Schizophrenen war die Glutaminsäure fast auf die Hälfte erniedrigt im Vergleich zu den Kontrollen mit Bandscheibenvorfällen. Der Glutaminsäuregehalt des Blutserums war bei allen drei Gruppen gleich hoch. Die meisten Huntington- und Schizophrenie-Patienten standen unter neuroleptischer Behandlung, nur eine Tochter eines Huntington-Patienten, bei der die Krankheit noch nicht manifest war, zeigte ebenfalls eine Glutaminsäureverminderung im Liquor. Da diese Patientin keine neuroleptischen Medikamente erhielt, ist es wahrscheinlicher, daß die Glutaminsäureverminderung durch die Erkrankung und nicht durch die neuroleptische Behandlung verursacht ist.
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References
Bruyn, G. W.: Huntington's chorea, historical, clinical and laboratory synopsis: In: Diseases of the basal ganglia, handbook of clinical neurology, P. J. Vinken and G. W. Bruyn (eds.), Vol. 6, pp. 298–378. Amsterdam: North Holland; New York: Wiley 1968
Graham, T., Aprison, M. H.: Fluorometric determination of Aspartate, Glutamate and γ-Aminobutyrate in nerve tissue using enzymic methods. Annal. Biochem. 15, 487–497 (1966)
Kim, J. S., Hassler, R., Haug, P., Paik, K. S.: Effect of frontal ablations on striatal glutamic acid level in rat. Brain Res. 132, 370–374 (1977)
Perry, T. L., Hansen, S., Lesk, D., Kloster, M.: Amino acids in plasma, cerebrospinal fluid, and brain of patients with Huntington's chorea. In: Advances in neurology, A. Barbeau, T. N. Chase and G. W. Paulson (eds.), Vol. 1, pp. 609–618. New York: Raven Press 1973
Streletzki, F.: Psychosen im Verlauf der Huntingtonschen Chorea under besonderer Berücksichtigung der Wahnbildungen. Arch. Psychiat. Nervenkr. 202, 202–214 (1961)
Zaczek, R., Hedreen, J. C., Coyle, J. P.: Evidence for a hippocampal-septal glutamatergic pathway in the rat. Exp. Neurol. 65, 145–156 (1979)
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Some of the Huntington's patients were under the care of Dr. K. Schröter, Dr. H. Pollok, and Dr. P. Rohrbach whose collaboration is gratefully acknowledged by the authors
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Kim, J.S., Kornhuber, H.H., Holzmüller, B. et al. Reduction of cerebrospinal fluid glutamic acid in huntington's chorea and in schizophrenic patients. Arch. Psychiatr. Nervenkr. 228, 7–10 (1980). https://doi.org/10.1007/BF00365738
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DOI: https://doi.org/10.1007/BF00365738