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Multiple allelic states of the cyh2 gene cause low- and high-level cycloheximide resistance in Saccharomyces cerevisiae

Summary

At least four different mutations at the cyh2 locus (rp1X; gene product: YL24) of Saccharomyces cerevisiae confer cycloheximide resistance. The mutant YL24 proteins are either more basic (high-level resistant phenotype), more acidic (low-level resistant phenotype), or unchanged in their electrophoretic mobility (both low-and high-level resistant phenotypes). None of the mutations at other loci seem to induce high-level resistance to cycloheximide.

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Correspondence to Wolfgang Piepersberg.

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Stöcklein, W., Jiménez, A., Littlewood, B. et al. Multiple allelic states of the cyh2 gene cause low- and high-level cycloheximide resistance in Saccharomyces cerevisiae . Current Genetics 5, 157–160 (1982). https://doi.org/10.1007/BF00365708

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Key words

  • Yeast
  • Cycloheximide
  • Ribosomal mutations