References
Blin, N. and Stafford, D.W.: A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res 3: 2303–2308, 1976.
Chowdhary, B.P., Harbitz, I., Davies, W., and Gustavsson, I.: Chromosomal localization of the glucose phosphate isomerase (GPI) gene in cattle, sheep and goat by in situ hybridization—chromosomal banding homology versus molecular conservation in Bovidae. Hereditas 114: 161–170, 1991.
Chowdhary, B.P., Harbitz, I., Davies, W., and Gustavsson, I.: Chromosomal localization of the calcium release channel (CRC) gene in cattle and horse by in situ hybridization—evidence of a conserved synteny with glucose phosphate isomerase. Anim Genet, in press, 1992.
Church, G. and Gilbert, W.: Genomic sequencing. Proc Natl Acad Sci USA 81: 1991–1995, 1984.
Echard, G., Gellin, J., Benne, F., and Gillois, M.: Progress in gene mapping in cattle and pigs using somatic cell hybridization. Human-gene mapping 7. Cytogenet Cell Genet 37: 458–459, 1984.
Feinberg, A.P. and Vogelstein, B.: A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132: 6–13, 1983.
Fries, R., Solinas, S., and Gunawardana, A.: Chromosomal assignment of marker loci to monitor marker spacing. In: L.B. Schook, H.A. Lewin, D.G. McLaren (eds.), Gene Mapping: Strategies, Techniques and Applications, pp 159–176 Marcel Dekker Inc., New York, 1991.
Harbitz, I., Chowdhary, B., Thomsen, P.D., Davies, W., Kaufmann, U., Kran, S., Gustavsson, I., Christensen, K., and Hauge J.G.: Assignment of the porcine calcium release channel gene, a candidate for the malignant hyperthermia locus, to the 6p11→q21 segment of chromosome 6. Genomics 8: 243–248, 1990.
Herz, J., Hamann, U., Rogne, S., Myklebost, O., Gausepohl, H., and Stanley, K.K.: Surface location and high affinity for calcium of a 500-kD liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J 7: 4119–4127, 1988.
Innerarity, T.L., Friedlander, E.J., Rall, S.C. Jr, Weisgraber, K.H., and Mahley, R.W.: The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments. J Biol Chem 258: 12341–12347, 1983.
ISCNDA (1989), International system for cytogenetic nomenclature of domestic animals Cytogenet Cell Genet 53: 65–79, 1990.
Kowal, R.C., Herz J., Goldstein, J.L., Esser, V., and Brown, M.S.: Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apolipoprotein E-enriched lipoproteins. Proc Natl Acad Sci USA 86: 5810–5814, 1989.
Lalazar, A., Weisgraber, K.H., Rall, S.C. Jr., Giladi, H., Innerarity, T.L., Levanon, A.Z., Boyles, J.K., Amit, B., Gorecki, M., Mahley, R.W., and Vogel, T.: Site specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions. J Biol Chem 263: 3542–3545, 1988.
Lusis, A.J., Heinzmann, C., Sparkes, R.S., Scott, J., Knott, T.J., Geller, R., Sparkes, M.C., and Mohandas, T.: Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1, -C2, and -E and LDLR) and the genes C3, PEPD, and GPI. Proc Natl Acad Sci USA 83: 3929–3933, 1986.
MacKenzie, A.E., Korneluk, R.G., Zorzato, F., Fujii, J., Phillips, M., Iles, D., Wieringa, B., Leblond, S., Bailly, J., and Willard, H.F.: The human ryanodine receptor gene: its mapping to 19q13.1, placement in a chromosome 19 linkage group, and exclusion as the gene causing myotonic dystrophy. Am J Hum Genet 46: 1082–1089, 1990.
Mahley, R.W.: Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240: 622–630, 1988.
Mahley, R.W. and Innerarity, T.L.: Lipoprotein receptors and cholesterol homeostasis. Biochim Biophys Acta 737: 197–222, 1983.
Mahley, R.W., Innerarity, T.L., Rall, S.C. Jr., and Weisgraber, K.H.: Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res 25: 1277–1294, 1984.
Maniatis, T., Fritsch, E.F., and Sambrook, J.: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1982.
Rall, S.C. Jr., Weisgraber, K.H., and Mahley, R.W.: Human apolipoprotein E. The complete amino acid sequence. J Biol Chem 257: 4171–4178, 1982.
Sambrook, J., Fritsch, E.F., and Maniatis, T.: Molecular Cloning: A Laboratory Manual 2nd edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989.
Threadgill, D.W. and Womack, J.E.: Syntenic conservation between humans and cattle. I. Human chromosome 9. Genomics 8: 22–28, 1990.
Verner, K., and Schatz, G.: Protein translocation across membranes. Science 241: 1307–1313, 1988.
Wallis, S.C., Rogne, S., Gill, L., Markham, A., Edge, M., Woods, D., Williamson, R., and Humphries, S.: The isolation of cDNA clones for human apolipoprotein E and the detection of apoE RNA in hepatic and extra-hepatic tissues. EMBO J 2: 2369–2373, 1983.
Womack, J.E. and Moll, Y.D.: gene map of the cow: conservation of linkage with mouse and man. J Hered 77: 2–7, 1986.
Yang, Y.-W., Chan, L., and Li, W.-H.: Cloning and sequencing of bovine apolipoprotein E complementary DNA and molecular evolution of apolipoproteins E, C-I, and C-II. J Mol Evol 32: 469–475, 1991.
Yerle, M., Gellin, J., Dalens, M., and Galman, O.: Localization on pig chromosome 6 of markers GPI, APOE, and ENO1, carried by human chromosomes 1 and 19, using in situ hybridization. Cytogenet Cell Genet 54: 86–91, 1990.
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The nucleotide sequence data reported in this paper have been submitted to EMBL Data Library and have been assigned the accession number: X64839 Bos taurus mRNA for apoprotein E.
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Brzozowska, A., Fries, R., Womack, J.E. et al. Isolation, sequencing, and expression analysis of a bovine apolipoprotein E (APOE) cDNA and chromosomal localization of the APOE locus. Mammalian Genome 4, 53–57 (1993). https://doi.org/10.1007/BF00364665
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DOI: https://doi.org/10.1007/BF00364665