Abstract
We present here the genetic mapping of the α-skeletal actin locus (Actsk-1) on mouse Chromosome (Chr) 8, on the basis of the PCR analysis of a microsatellite in an interspecific backcross. Linkage and genetic distances were established for four loci by analysis of 192 (or 222) meiotic events and indicated the following gene order: (centromere)-Es-1-11.7 cM-Tat-8.3 cM-Actsk-1-0.5 cM-Aprt. Mapping of ACTSK to human Chr 1 and of TAT and APRT to human Chr 16 demonstrates the existence of a new short region of homology between mouse Chr 8 and human Chr 1. Intermingling on this scale between human and mouse chromosomal homologies that occurred during evolution creates disorders in comparative linkage studies.
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Alonso, S., Montagutelli, X., Simon-Chazottes, D. et al. Re-localization of Actsk-1 to mouse Chromosome 8, a new region of homology with human Chromosome 1. Mammalian Genome 4, 15–20 (1993). https://doi.org/10.1007/BF00364657
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DOI: https://doi.org/10.1007/BF00364657