This is a preview of subscription content, log in via an institution to check access.
Abbreviations
- B10:
-
C57BL/IOSn
- C4:
-
fourth component of complement
- Slp:
-
sexlimited protein
- pro-C4:
-
precursor to C4
- NaDodSO4 :
-
sodium dodecyl sulfate
References
Carroll, M. C. and Capra, J. D.: Studies on murine Ss protein: Demonstration that the S locus encodes the structural gene for fourth component of complement. Proc. Natl. Acad. Sci. U.S.A. 76:4641–4645, 1979
Ferreira, A., Nussenzweig, V., and Gigh, I.: Structural and functional differences between the H-2 controlled Ss and Sip proteins. J. Exp. Med. 148:1186–1197, 1978
Ferreira, A., Michaelson, J., and Nussenzweig, V.: A polymorphism of the y-chain of mouse C4 controlled by the S region of the major histocompatibility complex. J. Immunol. 125:1178–1182, 1980a
Ferreira, A., Michaelson, J., and Nussenzweig, V.: H-2-controlled polymorphism of the γ-chain of Sip (sex-limited protein). Immunogenetics 11:491–497, 1980b
Fey, G., Odink, K., and Chapuis, R. M.: Synthesis of the mouse complement component C4 (Ss-protein) by peritoneal macrophages: Kinetics of secretion and glycosylation of the subunits. Eur. J. Immunol. 10:75–82, 1980
Karp, D. R., Atkinson, J. P., and Shreffler, D. C.: Genetic variation in glycosylation of the fourth component of murine complement: Association with hemolytic activity. J. Biol. Chem. in press. 1982a
Karp, D. R., Capra, J. D., Atkinson, J. P., and Shreffler, D. C.: Structural and functional characterization of an incompletely processed form of murine C4 and Sip. J. Immunol. 128:2336–2341, 1982b
Michaelson, J.: Genetic polymorphism of β2-microglobulin (B2m) maps to the H-3 region of chromosome 2. Immunogenetics 13 :167–171, 1981
Parker, K. L., Roos, M. H., and Shreffler, D. C.: Structural characterization of the murine fourth component of complement and sex-limited protein and their precursors: Evidence for two loci in the S region of the H-2 complex. Proc. Natl. Acad. Sci. U.S.A. 76:5853–5857, 1979
Parker, K. L., Atkinson, J. P., Roos, M. H., and Shreffler, D. C.: Genetic and structural characterization of H-2-controlled allelic forms of murine C4. Immunogenetics 11:55–63, 1980
Parker, K. L., Carroll, M. C., Shreffler, D. C., and Capra, J. D.: Identification of H-2 controlled allelic forms of the murine SIP protein and demonstration of cis-regulation of its expression. J. Immunol. 126:995–997, 1981
Passmore, H. C. and Shreffler, D. C.: A sex-limited protein variant in the mouse: Hormonal control of phenotypic expression. Biochem. Genet. 5:201–209, 1971
Ramanathan, L., DuBois, G. C., and Robinson, E. A.: Purification and characterization of mouse beta-2microglobulin variants from two different strains. Fed. Proc. 40:1817, 1981
Roos, M. H., Atkinson, J. P., and Shreffler, D. C.: Molecular characterization of the Ss and Slp (C4) proteins of the mouse H-2 complex: Subunit composition, chain size polymorphism, and an intracellular (pro-Ss) precursor. J. Immunol. 121:1106–1115, 1978
Roos, M. H., Shreffler, D. C., and Kornfeld, S.: Role of glycosylation on the proteolytic processing and secretion of the 4th component of complement (Ss protein) of the mouse. J. Immunol. 125: 1869–1871, 1980
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Karp, D.R., Shreffler, D.C. S region genetic control of murine C4 biosynthesis: Analysis of Pro-C4 cleavage. Immunogenetics 16, 171–176 (1982). https://doi.org/10.1007/BF00364403
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00364403