Abstract
The antibody response against the H-2.2 specificity has been studied in three H-2 dstrains, B10.D2, DBA/2, and BALB/c, and their hybrids (B10.D2 × DBA/2)F1 and (B10.D2 × BALB/c)F1. The genetic control of the response appears to be complex: The three pure strains are responders, whereas both hybrids when immunized with C3H-HTG are nonresponders. Individual analysis of N3 offspring is compatible with the idea that, in this combination, an Ea-4 incompatibility between donor and immunized strain is necessary for the anti-H-2.2 response to occur. H-2 d /H-2 k hybrids (B10.BR × B10.D2)F1 or (B10.BR × DBA/2)F1 are responders when immunized with C57BL/10 (H-2 b) but not with B10.A(2R) (H-2 h), indicating that simultaneously recognized H-2 specificities are necessary for the anti-H-2.2 response.
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Decoville, M., Motta, R. Interacting genetic factors controlling the antibody response against the H-2.2 specificity. Immunogenetics 15, 279–285 (1982). https://doi.org/10.1007/BF00364336
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DOI: https://doi.org/10.1007/BF00364336