Summary
The case of a young man with the plasmacell type of Castleman's disease is described. Beyond the well known systemic manifestations the coagulation tests showed a decrease in the activity of factors V, VIII and X due to the presence of lupus-like circulating anticoagulants. After surgical excision of the mediastinal mass both hematochemical pathological data and the coagulation defect desappeared. It is suggested that the lupus-like anticoagulant was secreted by the tumor.
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References
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Supported in part by Consiglio Nazionale delle Ricerche, Grant CT 82.02224.04
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Rizzo, S.C., Balduini, C.L., Gamba, G. et al. Castleman's disease with coagulation defect. Blut 49, 107–109 (1984). https://doi.org/10.1007/BF00363702
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DOI: https://doi.org/10.1007/BF00363702