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The 131I-iodide space of the rabbit

Part I Investigations on the fate of the 131I-label released by breakdown of iodinated proteins in the rabbit

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Summary

1. The 131I-iodide space (131IS) was repeatedly estimated in 10 rabbits kept on a special drinking water containing excess iodide and chloride. The mean 131IS was the 6.65 fold (±0.71) of the plasma volume or 253.7 ml plasma/kg of body weight.

2. Repeated estimations of 131IS in rabbits on drinking water containing only excess iodide have shown a mean 131IS equivalent to 7.64 fold plasma volume (±0.81) or 302.9 ml plasma/kg b.w.

3. The 131IS of rabbits on plain water averaged a plasma volume factor 7.84 (±1.02) or 280.0 ml plasma/kg body weight.

4. The influence of thyroidectomy, operative trauma, narcosis and repeated haemorrhage on the 131IS is investigated and presented.

5. A detailed picture is given of the composition of 131IS in normal, thyreoidectomised and KClO4-treated rabbits.

6. The activities of 131I in the extravascular water of the rabbit's organs are shown.

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Authors and Affiliations

  1. From the Biophysics Department of the National Institute for Medical Research, The Ridgeway, Mill Hill, N. W. 7, London

    E. Regoeczi

  2. Wenckebach-Krankenhaus, Wenckebachstr. 23, 1 Berlin-Tempelhof

    E. Regoeczi

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  1. E. Regoeczi
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Regoeczi, E. The 131I-iodide space of the rabbit. Pflügers Archiv 276, 600–609 (1963). https://doi.org/10.1007/BF00363565

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  • DOI: https://doi.org/10.1007/BF00363565

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