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Möglichkeiten der Konzentrierung von Stoffen in biologischen Gegenstromsystemen

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Summary

It was shown by model experiments that:

  1. 1.

    A countercurrent system with permeable walls can multiply a single concentration effect by diffusion (diffusion multiplier), if the single effect is produced by evaporation of water;

  2. 2.

    A countercurrent system with semipermeable walls can multiply a single concentration effect by osmosis (osmotic multiplier), if the single effect is produced by addition of an osmotic substance.

By reason of these results a new hypothesis of the concentration mechanism in the kidney is presented: according to it an osmotic substance is produced in the tubulus system so that firstly the tubulus system works as an osmotic multiplier and secondly water is extracted from the vasa recta system by the tubuli, so that the vasa recta system will work as diffusion multiplier.

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Authors and Affiliations

  1. Aus dem Physiologischen Institut der Universität Kiel, Germany

    W. Niesel & H. Röskenbleck

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  1. W. Niesel
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  2. H. Röskenbleck
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Niesel, W., Röskenbleck, H. Möglichkeiten der Konzentrierung von Stoffen in biologischen Gegenstromsystemen. Pflügers Archiv 276, 555–567 (1963). https://doi.org/10.1007/BF00363561

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  • DOI: https://doi.org/10.1007/BF00363561

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