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Die Restitution der automatischen Erregungsbildung in Kalium-gelähmten Schrittmacher-Geweben durch Adrenalin

Elektrophysiologische Studien am isolierten Sinusknoten (Meerschweinchen, Rhesusaffe) sowie am Purkinje-Faden (Rhesusaffe)

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Summary

Spontaneous rhythmic activity of isolated cardiac pacemakers is completely suppressed by sufficiently increasing the extracellular potassium concentration. Adrenaline was found to restore spontaneous activity of the guinea pig's sinus node as well as of the monkey's sinus and Purkinje fibres. Microelectrode measurements were performed in order to elucidate the mechanisms of action.

High extracellular potassium mainly acts by reducing the maximal diastolic potential and the rate of diastolic depolarization to such an extent that generation of propagated impulses is no more possible. In Purkinje fibres, being most sensitive to potassium, spontaneous beating frequently ceased without any reduction of the maximal diastolic potential. Here, the inhibitory effect of high potassium is considerably supported by the decrease of the threshold potential which regularly occurs in a potassium rich medium.

Adrenaline restarts spontaneous activity by increasing the steepness of the diastolic depolarization and by elevating the threshold potential. Local oscillations of the membrane potential often precede propagated impulses. Besides these effects, closely connected with rhythmic activity, adrenaline increases the overshoot and prolongs the duration of the action potential without any direct influence on the maximal rate of rise.

The specific mechanisms of action of potassium ions and adrenaline are discussed in detail.

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Authors and Affiliations

  1. Aus dem Physiologischen Institut der Universität Freiburg i.Br., Germany

    H. Antoni, K. Herkel & A. Fleckenstein

Authors
  1. H. Antoni
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  2. K. Herkel
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  3. A. Fleckenstein
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Additional information

Herrn Prof. Dr. A. v. Muralt zum 60. Geburtstag gewidmet.

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Der wesentliche Inhalt der vorliegenden Publikation wurde von Fräulein Karin Herkel im Juli 1963 an der Med. Fakultät der Universität Freiburg i. Br. als Dissertation vorgelegt.

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Antoni, H., Herkel, K. & Fleckenstein, A. Die Restitution der automatischen Erregungsbildung in Kalium-gelähmten Schrittmacher-Geweben durch Adrenalin. Pflügers Archiv 277, 633–649 (1963). https://doi.org/10.1007/BF00363282

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  • DOI: https://doi.org/10.1007/BF00363282

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