Skip to main content
SpringerLink
Log in

Gibt es eine Doppelinnervation im menschlichen Muskel?

Mechanographische Untersuchungen am Hypothenar

  • Published:
Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere Aims and scope Submit manuscript

Summary

By using a special technique of double stimulations, it is possible to obtain an exact functional subdivision within the peripheral motor neuron into separate conducting fiber bundles. The ulnar nerve was chosen for this investigation because of the great length the nerve offers for study. The mechanical effect of the hypothenar was recorded. The following results were obtained:

  1. 1.

    If the two bundles of nerve fibers were stimulated one after another at an interval of 15 msec, then the sum of the mechanical response clearly exceeded the response obtained by simultaneous stimulation of all the nerve fibers.

  2. 2.

    The effect was no longer manifest as soon as the the time interval of the stimuli dropped below the refractory time of the peripheral synapse (2 msec).

These results can only be explained if it is assumed that in the first instance part of the muscle fibers can be activated through two or more motor neurons. This is, moreover, an appreciable part and amounts to about 30% of the entire muscle mass. Double innervation of the motor end plates to such an extent certainly does not exist anatomically. We are, therefore, discussing the possibility of “axone reflexes” in the terminal areas of the motor neurons.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Adrian, E. D.: The spread of activity in the tenussimus muscle of the cat and in other complex muscles. J. Physiol. (Lond.) 60, 301–315 (1925).

    Google Scholar 

  • Adrian, E. D., and D. W. Bronk: The discharge of impulses in motor nerve fibres II. J. Physiol. (Lond.) 67, 119–151 (1929).

    Google Scholar 

  • Adrian, E. D., and K. Lucas: On the summation of propagated disturbances in nerve and muscle. J. Physiol. (Lond.) 44, 68–124 (1912).

    Google Scholar 

  • Agduhr, E.: Über die plurisegmentale Innervation der einzelnen quergestreiften Muskelfasern. Anat. Anz. 52, 273–291 (1919).

    Google Scholar 

  • Agduhr, E.: On the Innervation of cross-striated muscle fibers. Upsala Läk.-Fören. Förh. 45, 399–418 (1939).

    Google Scholar 

  • Beritoff, J.: Physiologischer Beweis der plurisegmentellen Innervation der quergestreiften Muskelfasern. Pflügers Arch. ges. Physiol. 205, 455–557 (1924).

    Google Scholar 

  • Boyd, M.: Monosegmental versus plurisegmental Innervation of the gastrocnemius and peroneus muscles of the frog. Amer. J. Physiol. 78, 254–258 (1926).

    Google Scholar 

  • Brown, M. C., and P. B. C. Matthews: A possible explanation of the different contractions of muscle produced by synchronous and asynchronous motor volleys. J. Physiol. (Lond.) 148, 27–28 (1959).

    Google Scholar 

  • Brown, M. C., and P. B. C. Matthews: The effect on a muscle twitch of the back-response of its motor nerve fibres. J. Physiol. (Lond.) 150, 332–346 (1960).

    Google Scholar 

  • Cajal, S. Ramon y: Histologie du Système nerveux. Instituto Ramon y Cajal, Madrid, 1955, Tome 1, p. 286.

  • Cattell, C.: Plurisegmental innervation in the frog. J. Physiol. (Lond.) 66, 431 bis 442 (1928).

    Google Scholar 

  • Christensen, E.: Topography of terminal motor nerv innervation in striated muscle from stillborne infants. Amer. J. phys. Med. 38, 79–86 (1959).

    Google Scholar 

  • Coërs, C., and A. L. Woolf: The innervation of Muscle. Oxford: Blackwell 1959.

    Google Scholar 

  • Cole, W. V.: Anat. Rec. 98, 393 (1947); zit. nach Jarcho u. Mitarb. (1952).

    Google Scholar 

  • Cooper, S.: The relation of active to inactive fibres in fractional contraction of muscle. J. Physiol. (Lond.) 67, 1–13 (1929).

    Google Scholar 

  • Denny-Brown, D., and J. B. Pennybacker: Fibrillation and fasciculation in voluntary muscle. Brain 61, 311–334 (1938).

    Google Scholar 

  • Diamond, J., J. A. B. Gray and D. R. Inman: The depression of the receptor potential in Paccinian corpuscles. J. Physiol. (Lond.) 141, 117–131 (1958).

    Google Scholar 

  • Diamond, J., J. A. B. Gray and M. Sato: The site of initiation of impulses in Paccinian corpuscles. J. Physiol. (Lond.) 133, 54–67 (1956).

    Google Scholar 

  • Eccles, J. C., and W. J. O'Conner: Responses which nerve impulses evoke in mammalian striated muscle. J. Physiol. (Lond.) 97, 44–102 (1939).

    Google Scholar 

  • Eccles, J. C., and C. S. Sherrington: Numbers and contraction values of individual motor units examined in some muscles of the limb. Proc. roy. Soc. B. 106, 326–357 (1930).

    Google Scholar 

  • Exner, S.: Notiz zu der Frage von der Faserverteilung mehrerer Nerven in einem Muskel. Pflügers Arch. ges. Physiol. 36, 572 (1885).

    Google Scholar 

  • Feindel, W., J. R. Hinshaw and G. Weddell: The pattern of motor innervation in mammalian striated muscle. J. Anat. (Lond.) 86, 35–48 (1952).

    Google Scholar 

  • Fulton, J. F.: Muscular contraction and the Reflex Control of movement. Baltimore 1926.

  • Fulton, J. F.: Physiologie des Nervensystems. Stuttgart: Enke 1952.

    Google Scholar 

  • Furshpan, E. J.: Neuromuscular transmission in invertebrates. Handbook of Neurophysiology, I, p. 239 ff. Baltimore: Williams & Wilkins 1959.

    Google Scholar 

  • Garven, H. S. D.: Brain 48, 380 (1925); zit. nach Jarcho u. Mitarb. 1952.

    Google Scholar 

  • Hinsey, J. C.: The innervation of skeletal muscle. Physiol. Rev. 14, 514–585 (1934).

    Google Scholar 

  • Hoffman, H.: Collateral reinnervation in partially denervated muscle. Amer. J. phys. Med. 38, 36–39 (1959).

    Google Scholar 

  • Hoffmann, P.: Das Verhalten zweier Erregungswellen, die sich in der Muskelfaser begegnen. Z. Biol. 70, 515–524 (1913).

    Google Scholar 

  • Hunt, C. C., and S. W. Kuffler: Further study of efferent small-nerve fibres to mammalian muscle-spindles. Multiple spindle innervation and activity during contraction. J. Physiol. (Lond.) 113, 283–297 (1951).

    Google Scholar 

  • Hunt, C. C., and S. W. Kuffler: Motor innervation of skeletal muscle: Multiple Innervation of individual muscle fibres and motor unit function. J. Physiol. (Lond.) 126, 293–303 (1954).

    Google Scholar 

  • Jarcho, L. W., C. Eyzaguirre, B. Berman and J. L. Lilienthal Jr.: Spread of excitation in skeletal muscle, some factors, contributing to the form of the Elektromyogramm. Amer. J. Physiol. 168, 446–465 (1952).

    Google Scholar 

  • Katz, L. N.: Proc. roy. Soc. B. 99, 1 (1925); zit. nach Cattell (1928).

    Google Scholar 

  • Katz, B., and S. W. Kuffler: Multiple motor innervation of the frogs sartorius muscle. J. Neurophysiol. 4, 209–223 (1941).

    Google Scholar 

  • Lederer, R., u. F. Lemberger: Zur Frage der doppelten Innervation von Muskeln des Warmblüters. Pflügers Arch. ges. Physiol. 119, 95–101 (1907).

    Google Scholar 

  • Liddell, E. G. T., and C. S. Sherrington: Proc. roy. Soc. B. 97, 488–518 (1925); zit. nach Denny-Brown und Pennybacker (1938).

    Google Scholar 

  • Lloyd, D. P. C.: Stimulation of peripheral nerve terminations by active muscle. J. Neurophysiol. 5, 153–165 (1942).

    Google Scholar 

  • Ludin, H. P.: Elektromyographische Untersuchungen über die funktionelle Gliederung motorischer Einheiten. Fortschr. Neurol. Psychiat. 29, 429–444 (1961).

    Google Scholar 

  • Merton, P. A.: Contractions of muscle produced by synchronous and asynchronous motor volleys. J. Physiol. (Lond.) 112, 6–7 P. (1951).

    Google Scholar 

  • Merton, P. A.: Interaction between muscle fibres in a twitch. J. Physiol. (Lond.) 124, 311–324 (1954).

    Google Scholar 

  • Ralston, H. J., and B. Libet: Effect of stretch on active potential of voluntary muscle. Amer. J. Physiol. 173, 449–455 (1953).

    Google Scholar 

  • Reichel, H.: Muskelphysiologie. Berlin, Göttingen, Heidelberg: Springer 1960.

    Google Scholar 

  • Sherrington, C. S.: Proc. roy. Soc. B. 105, 332–362 (1929); zit. nach Denny-Brown und Pennybacker (1938).

    Google Scholar 

  • Sherrington, C. S.: Brain 54, 1–28 (1931); zit. nach Denny-Brown und Pennybacker (1938).

    Google Scholar 

  • Stämpfli, R.: Bau und Funktion isolierter markhaltiger Nervenfasern. Ergebn. Physiol. 47, 70–165 (1952).

    Google Scholar 

  • Stockey, B.: An experimental study of hyperneurotization. Arch. Neurol. Psychiat. (Chicago) 11, 113–120 (1924).

    Google Scholar 

  • Sunderland, S.: The multiple motor innervation of individual muscle fibres in man. Acta Anat. (Basel) 16, 167–168 (1952).

    Google Scholar 

  • Tiegs, O. W.: Innervation of voluntary muscle. Physiol. Rev. 33, 90–172 (1953).

    Google Scholar 

  • Werner, G.: Neuromuscular facilitation and antidromic discharges in motor nerves: Their relation to activity in motor nerve terminals. J. Neurophysiol. 23, 171–187 (1960 a).

    Google Scholar 

  • Werner, G.: Generation of antidromic activity in motor nerves. J. Neurophysiol. 23, 453–461 (1960 b).

    Google Scholar 

  • Werner, G.: Antidromic activity in motor nerves and its relation to a generator event in nerve terminals. J. Neurophysiol. 24, 401–413 (1961).

    Google Scholar 

  • Wilkinson, H. J.: Muskelfasern erhalten ihre Versorgung von einem Plexus, wozu alle motorischen Fasern beitragen. Bull. Histol. appl. 8, 117–154 (1931).

    Google Scholar 

  • Wohlfart, G.: Clinical considerations on innervation of skeletal muscle. Amer. J. phys. Med. 38, 223–230 (1959).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Aus der Neurologischen Universitätsklinik, Würzburg

    Hanns Christian Hopf & Hans-Joachim Hufschmidt

Authors
  1. Hanns Christian Hopf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hans-Joachim Hufschmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Mit 5 Textabbildungen

Mit dankenswerter Unterstützung der Deutschen Forschungsgemeinschaft.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hopf, H.C., Hufschmidt, HJ. Gibt es eine Doppelinnervation im menschlichen Muskel?. Pflügers Archiv 275, 152–163 (1962). https://doi.org/10.1007/BF00363137

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00363137

Search

Navigation