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Die frühdistale Natriumkonzentration in Rattennieren nach renaler Ischämie und hämorrhagischer Hypotension

Ein Beitrag zur Pathogenese der postischämischen und posthämorrhagischen Filtraterniedrigung

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Summary

In micropuncture experiments on rat kidneys early distal sodium concentration, approximating that of the macula densa site, together with glomerular filtration rate and renal excretory function were determined before and after renal ischemia or hemorrhagic hypotension. In the ischemia experiments micro-puncture samples were obtained using the same early distal puncture site of distal convolutions before and after ischemia.

Early distal [Na+] was found to be increased after ischemia or hypotension, in some experiments approaching plasma [Na+]. The degree of increased [Na+] was inversely related to GFR. In order to eliminate the influence of reduced tubular flow rate which occurs after renal ischemia, single loops of Henle were perfused at a constant rate and the increase in early distal [Na+] was found to be in the same range of magnitude. U/P inulin was decreased after renal ischemia. U Na·V and urine volume were increased in most experiments.

The results indicate that the ability of the ascending limb of Henle's loop to establish a [Na+] gradient across the tubular wall is reduced after renal ischemia or hemorrhagic hypotension. According to the hypothesis that GFR is regulated by [Na+] at the macula densa cells, it is suggested that persistent renal vasoconstriction and fall in GFR following renal damage is caused by the elevated [Na+] of the tubular fluid in the macula densa segment. It is concluded that reduction of RBF and GFR after renal damage is the response to decreased tubular Na+ reabsorption, and that the renin angiotensin system participates in this reaction at the level of the juxtaglomerular apparatus. The reaction is considered as a Na+-conserving mechanism.

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Mit Unterstützung der Deutschen Forschungsgemeinschaft und des U.S. Department of the Army, European Research Office.

Auszugsweise vorgetragen auf der 30. Tagung (Frühjahrstagung) der Dtsch. Physiolog. Gesellschaft, Bad Nauheim 1965.

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Schnermann, J., Nagel, W. & Thurau, K. Die frühdistale Natriumkonzentration in Rattennieren nach renaler Ischämie und hämorrhagischer Hypotension. Pflügers Archiv 287, 296–310 (1966). https://doi.org/10.1007/BF00362491

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  • DOI: https://doi.org/10.1007/BF00362491

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