Abstract
In normal children, fractures of the femoral neck are uncommon and accompany severe trauma and multiple injuries elsewhere in the skeleton [16, 17]. In children with Gaucher disease, a rare hereditary disorder of lipid metabolism, midcervical or basicervical fractures can occur with minor or no trauma and without other injury to the skeleton. Three children with Gaucher disease who developed pathologic fractures of the femoral neck are described. In all three, the fractures occurred between five and nine years of age, and the fracture lines passed through areas of abnormal bone characterized by poorly defined patches of increased and decreased density and cortical thinning along the medial femoral necks. In the affected hips, there was no evidence of avascular necrosis of the femoral heads at the time of injury. One child's fracture was preceeded by multiple bone “crises” localized to the proximal femora.
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Goldman, A.B., Jacobs, B. Femoral neck fractures complicating gaucher disease in children. Skeletal Radiol 12, 162–168 (1984). https://doi.org/10.1007/BF00361082
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DOI: https://doi.org/10.1007/BF00361082