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Chromosomal localization of HSP70 genes in cattle

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Abstract

Five genomic clones representing three HSP70 genes of cattle were biotin labeled and independently hybridized to cattle chromosomes. Fluorescence in situ hybridization localized HSP70-2 to Chromosome (Chr) 23 band 22 (the BoLA region), HSP70-3 to Chr 10 band 34, and HSP70-4 to Chr 3 band 13. Since HSP70-1, a fourth HSP70 gene, is tightly linked with HSP70-2 and the BOLA@, HSP70-1 was also localized to Chr 23 band 22. The localization of HSP70-4 is the first assignment of a cattle U6 marker; thus, this entire syntenic group is tentatively placed in cattle Chr 3.

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References

  • Fries, R., Hediger, R., Stranzinger, G., (1986). Tentative chromosomal localization of the bovine major histocompatibility complex by in situ hybridization. Anim. Genet. 17, 287–294.

    Google Scholar 

  • Fries, R., Threadgill, D.W., Hediger, R., Gunawardana, A., Blessing, M., Jorcano, J.L., Stranzinger, G., Womack, J.E. (1991). Mapping of bovine cytokeratin sequences to four different sites on three chromosomes. Cytogenet. Cell Genet. 57, 135–141.

    Google Scholar 

  • Gallagher, D.S., Jr., Womack, J.E. (1992). Chromosome conservation in the Bovidae. J. Hered. 83, 287–298.

    Google Scholar 

  • Gallagher, D.S., Jr., Basrur, P.K., Womack, J.E. (1992). Identification of an autosome to X chromosome translocation in the domestic cow. J. Hered. 83, 451–453.

    Google Scholar 

  • Georges, M., Gunawardana, A., Threadgill, D.W., Lathrop, M., Olsaker, I., Mishra, A., Sargeant, L.L., Schoeberlein, A., Steele, M.R., Terry, C., Threadgill, D.S., Zhao, X., Holm, T., Fries, R., Womack, J.E. (1991). Characterization of a set of variable number of tandem repeat markers conserved in Bovidae. Genomics 11, 24–32.

    Google Scholar 

  • Grosz, M.D. (1992). Molecular genetics of bovine 70 kilodalton heat shock protein (HSP70) genes. PhD dissertation, (College Station, Texas: Department of Veterinary Anatomy, College of Veterinary Medicine, Texas A&M University).

  • Grosz, M.D., Womack, J.E., Skow, L.C. (1992). Syntenic conservation of HSP70 genes in cattle and humans. Genomics 14, 863–868.

    Google Scholar 

  • Harrison, G.S., Drabkin, H.A., Kao, F., Hartz, J., Hart, I.M., Chu, E.H.Y., Wu, B., Morimoto, R. (1987). Chromosomal location of human genes encoding major heat shock protein HSP70. Somatic Cell Mol. Genet. 13, 119–130.

    Google Scholar 

  • Hunt, C.R., Gasser, D.L., Chaplin, D.D., Pierce, J.C., Kozak, C.A. (1993). Chromosomal localization of five murine HSP70 gene family members: Hsp70-1, Hsp70-2, Hsp70-3, Hsc70t and Grp78. Genomics 16, 193–198.

    Google Scholar 

  • Iannuzzi, L., Gallagher, D.S., Womack, J.E., DiMeo, G.P., Skow, L.C., Ferrara, L. (1993). Chromosomal localization of the major histocompatibility complex in cattle and river buffalo by fluorescent in situ hybridization. Hereditas 118, in press.

  • ISCNDA 1989 (1990). International System for Cytogenetic Nomenclature of Domestic Animals. D. Di Berardino, H. Hayes, R. Fries, S. Long, eds. Cytogenet. Cell Genet. 53, 65–79.

  • Leung, T.K.C., Hall, C., Rajendran, M., Spurr, N., Lim, L. (1992). The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. Genomics 12, 74–79.

    Google Scholar 

  • Lindquist, S., Craig, E.A. (1988). The heat shock proteins. Annu. Rev. Genet. 22, 631–677.

    Google Scholar 

  • Milner, C.M., Campbell, R.D. (1990). Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 32, 242–251.

    Google Scholar 

  • Reading Conference (1980), Proceedings of the First International Conference for the Standardization of Banded Karyotypes of Domestic Animals, Reading, England, 1976, C.E. Ford, D.L. Pollack, I. Gustavsson, eds. Hereditas 92, 145–162.

  • Ryan, A.M., Gallagher, D.S., Womack, J.E. (1992). Syntenic mapping and chromosomal localization of bovine α and β interferon genes. Mammalian Genome 3, 575–578.

    Google Scholar 

  • Schlesinger, M.J. (1990). Heat shock proteins. J. Biol. Chem. 21, 12111–12114.

    Google Scholar 

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Gallagher, D.S., Grosz, M.D., Womack, J.E. et al. Chromosomal localization of HSP70 genes in cattle. Mammalian Genome 4, 388–390 (1993). https://doi.org/10.1007/BF00360590

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  • DOI: https://doi.org/10.1007/BF00360590

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