Abstract
Copy numbers and variation of a clustered long-range repeat family on Chromosome (Chr) 1 have been studied in different species of the genus Mus. The repeat sequence was present in all, as inferred from cross-hybridization with probes derived from the Mus musculus repeat family. Copy numbers determined by dot blot hybridization were very low, from three to six per haploid genome in M. caroli, M. cervicolor, and M. cookii. These species form one branch of the phylogenetic tree in the genus Mus. In the other group of phylogenetically related species—M. spicilegus, M. spretus, M. musculus and M. macedonicus—copy numbers ranged from 6 to 1810 per haploid genome. The repeat cluster is cytogenetically visible as a fine C-band in M. macedonicus and as a C-band positive homogeneously staining region (HSR) in several populations of M. m. domesticus and M. m. musculus. When cytogenetically visible, the clusters contained from 179 to 1810 repeats. Intragenomic restriction fragment length polymorphisms (RFLPs), which reflect sequence variation among different copies of the long-range repeat family, increased with higher copy numbers. The high similarity of the RFLP pattern among genomes with C-band positive regions in Chr 1 of M. m. musculus, M. m. domesticus, and M. macedonicus points to a close evolutionary relationship of their Chr 1 repeat families.
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Agulnik, S.I., Agulnik, A.I., Ruvinsky, A.O. (1990a). Meiotic drive in female mice heterozygous for the HSR inserts on chromosome 1. Genet. Res. 55, 97–100.
Agulnik, S.I., Borodin, P.M., Gorlov, I.P., Ladygina, T.Yu., Pak, S.D. (1990b). The origin of a double insertion of homogenously staining regions in the house mouse (Mus musculus). Heredity 65, 265–267.
Agulnik, S., Adolph, S., Winking, H., Traut, W. (1993a). Zoogeography of the chromosome 1 HSR in natural populations of the house mouse (Mus musculus). Hereditas, in press.
Agulnik, S.I., Sabantsev, I.D., Orlova, G.V., Ruvinsky, A.O. (1993b). Meiotic drive on aberrant chromosome 1 in the mouse is determined by a linked distorter. Genet. Res. 61, 91–96.
Agulnik, S.I., Sabantsev, I.D., Ruvinsky, A.O. (1993c). Effect of sperm genotype on chromatid segregation in female mice heterozygous for aberrant chromosome 1. Genet. Res. 61, 97–100.
Alonso, S., Minty, A., Bourlet, Y., Buckingham, M. (1986). Comparison of three actin-coding sequences in the mouse; evolutionary relationships between the actin genes of warm-blooded vertebrates. J. Mol. Evol. 23, 11–22.
Bonhomme, F. (1986). Evolutionary relationships in the genus Mus. Curr. Top. Microbiol. Immunol. 127, 19–34.
Bulatova, N., Kotenkova, E. (1990). Variants of the Y-chromosome in sympatric taxa of Mus in Southern USSR. Boll. Zool. 57, 357–360.
Eckert, W.A., Plass, C., Weith, A., Traut, W., Winking, H. (1991). Transcripts from amplified sequences of an inherited homogeneously staining region in chromosome 1 of the house mouse (Mus musculus). Mol. Cell. Biol. 11, 2229–2235.
Hsu, T.C., Markvong, A., Marshall, J.T. (1978). G-band patterns of six species of mice belonging to the subgenus Mus. Cytogenet. Cell Genet. 20, 304–307.
Markvong, A. (1977). Cytogenetic studies of genus Mus (Rodentia, Muridae) with special references to species from Thailand. Dissertation, The University of Arizona.
Moriwaki, K., Miyashita, N., Suzuki, H., Kurihara, Y., Yonekawa, H. (1986). Genetic features of major geographical isolates of Mus musculus. Curr. Top. Microbiol. Immunol. 127, 55–61.
Nei, M., Li, W.H. (1979). Mathematical model for studying genetic variation in terms of restriction endonucleases. Proc. Natl. Acad. Sci. USA 76, 5269–5273.
Plass, C., Hellwig, T., Traut, W., Winking, H. (1992). Evolution of a B2 tagged sequence from a long-range repeat family in the genus Mus. Mammalian Genome 3, 197–201.
Purmann, L., Plass, C., Grüneberg, M., Winking H., Traut, W. (1992). A long-range repeat cluster in Chromosome 1 of the house mouse, Mus musculus, and its relation to a germline homogeneously staining region. Genomics 12, 80–88.
Sharma, T., Cheong, N., Sen, S., Sen, P. (1986). Constitutive heterochromatin and evolutionary divergence of Mus dunni, M. booduga and M. musculus. Curr. Top. Microbiol. Immunol. 127, 35–44.
She, J.X., Bonhomme, F., Boursot, P., Thaler, L., Catzeflis, F. (1990). Molecular phylogenies in the genus Mus: comparative analysis of electrophoretic, scnDNA hybridization, and mtDNA RFLP data. Biol. J. Linn. Soc. 41, 83–103.
Silver, L.M. (1993). The peculiar journey of a selfish chromosome: mouse t haplotypes and meiotic drive. Trends Genet 9, 250–254.
Stark, G.K., Debatisse, M., Wahl, M., Glover, D.M. (1990). DNA amplification in eukaryotes. In: Gene Rearrangement, B.D. Hames, D.M. Glover, eds. (Oxford: Oxford University Press), pp. 99–149.
Sumner, A.T. (1972). A simple technique for demonstrating centromeric heterochromatin. Exp. Cell Res. 75, 304–306.
Szostecki, C., Guldner, H.H., Netter, H.J., Will, H. (1991). Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis. J. Immunol. 145, 4338–4347.
Traut, W., Winking, H., Adolph, S. (1984). An extra segment in chromosome 1 of wild Mus musculus: a C-band positive homogeneously staining region. Cytogenet. Cell Genet. 38, 290–297.
Traut, W., Seldin, M.F., Winking, H. (1992). Genetic mapping and assignment of a long-range repeat cluster to band D of Chromosome 1 in Mus musculus and M. spretus. Cytogenet. Cell Genet. 60, 128–130.
Traut, W., Winking, H., Plass, C., Weichenhan, D., Kunze, B., Hellwig, T., Agulnik, S. (1993). An inherited homogeneously staining region derived from a long-range repeat family in the house mouse. In: Chromosomal Alterations, Origin and Significance, G. Obe, A.T. Natarajan, eds. (Berlin: Springer Verlag), in press.
Weith, A., Winking, H., Brackmann, B., Boldyreff, B., Traut, W. (1987). Microclones from a germ line HSR detect amplification and complex rearrangements of DNA sequences. EMBO J. 6, 1295–1300.
Winking, H., Weith, A., Boldyreff, B., Moriwaki, K., Fregda, K., Traut, W. (1991). Polymorphic HSRs in chromosome 1 of the two semispecies Mus musculus musculus and M. m. domesticus have a common origin in an ancestral population. Chromosoma 100, 147–151.
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Agulnik, S., Plass, C., Traut, W. et al. Evolution of a long-range repeat family in Chromosome 1 of the genus Mus . Mammalian Genome 4, 704–710 (1993). https://doi.org/10.1007/BF00357793
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DOI: https://doi.org/10.1007/BF00357793