Identification of sudomotor activity in cutaneous sympathetic nerves using sweat expulsion as the effector response

  • J. Sugenoya
  • S. Iwase
  • T. Mano
  • T. Ogawa
Article

Summary

In a warm environment at ambient temperatures between 25° and 38°C (relative humidity 50%–60%) the relationship between sympathetic activity in cutaneous nerves (SSA) and pulses of sweat expulsion was investigated in five young male subjects. The SSA was recorded from the peroneal nerve using a microelectrode. Sweat expulsion was identified on the sweat rate records obtained from skin areas on the dorsal side of the foot, for spontaneous sweating and drug-induced sweating, using capacitance hygrometry. Sweat expulsion was always preceded by bursts of SSA with latencies of 2.4–3.0 s. This temporal relationship between bursts of SSA and sweat expulsion was noted not only in various degrees of thermal sweating but also in the sweating evoked by arousal stimuli, or by painful electric stimulation. The amplitude of the sudomotor burst was linearly related to the maximal rate of increase of the corresponding sweat expulsion, the amplitude of the expulsion and the integrated amount of sweat produced for the duration of the expulsion. The results provide direct evidence that sweat expulsion reflects directly centrally-derived sudomotor activity.

Key words

Microneurography Thermal sweating Sudomotor activity Vasoconstriction Laser-Doppler flowmetry 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams T, Vaughan JA (1965) Human eccrine sweat gland activity and palmar electrical skin resistance. J Appl Physiol 20:980–983Google Scholar
  2. Bini G, Hagbarth K-E, Hynninen P, Wallin BG (1980a) Thermoregulatory and rhythm-generating mechanisms governing the sudomotor and vasoconstrictor outflow in human cutaneous nerves. J Physiol (Lond) 306:537–552Google Scholar
  3. Bini G, Hagbarth K-E, Hynninen P, Wallin BG (1980b) Regional similarities and differences in thermoregulatory vaso- and sudomotor tone. J Physiol (Lond) 306:553–565Google Scholar
  4. Blumberg H, Wallin BG (1987) Direct evidence of neurally mediated vasodilatation in hairy skin of the human foot. J Physiol (Lond) 382:105–121Google Scholar
  5. Delius W, Hagbarth K-E, Hongell A, Wallin BG (1972) Manoeuvres affecting sympathetic outflow in human skin nerves. Acta Physiol scand 84:177–186Google Scholar
  6. Edelberg R (1964a) Independence of galvanic skin response amplitude and sweat production. J Invest Dermatol 42:443–448Google Scholar
  7. Edelberg R (1964b) Effect of vasoconstriction on galvanic skin response amplitude. J Appl Physiol 19:427–430Google Scholar
  8. Fagius J, Wallin BG (1980) Sympathetic reflex latencies and conduction velocities in normal man. J Neuro Sci 47:433–448Google Scholar
  9. Fox RH, Hilton SM (1958) Bradykinin formation in human skin as a factor in heat vasodilatation. J Physiol (Lond) 142:219–232Google Scholar
  10. Hagbarth K-E, Hallin RG, Hongell A, Torebjörk HE, Wallin BG (1972) General characteristics of sympathetic activity in human skin nerves. Acta Physiol Scand 84:164–176Google Scholar
  11. Hallin RG, Torebjörk HE (1970) Afferent and efferent C units recorded from human skin nerves in situ. Acta Soc Med Ups 75:277–281Google Scholar
  12. Iwase S, Mano T, Sugenoya J, Saito M, Hakusui S (1988) Relationship among skin sympathetic nerve activity, sweating, and skin blood flow. Environ Med 32:55–67Google Scholar
  13. Jänig W, Kümmel H (1977) Functional discrimination of postganglionic neurones to the cat's hindpaw with respect to the skin potentials recorded from the hairless skin. Pflügers Arch 371:217–225Google Scholar
  14. Lidberg L, Wallin BG (1981) Sympathetic skin nerve discharges in relation to amplitude of skin resistance responses. Psychophysiology 18:268–270Google Scholar
  15. Lindh B, Haegerstrand A, Lundberg JM, Hökfelt T, Fahrenkrug J, Cuello AC, Graffi J, Massoulié J (1988) Substance P-, VIP- and CGRP-like immunoreactivities coexist in a population of cholinergic postganglionic sympathetic nerves innervating sweat glands in the cat. Acta Physiol Scand 134:569–570Google Scholar
  16. Lundberg JM, Änggård A, Fahrenkrug J, Hökfelt T, Mutt V (1980) Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: functional significance of coexisting transmitters for vasodilation and secretion. Proc Natl Acad Sci USA 77:1651–1655Google Scholar
  17. Nakayama T, Takagi K (1959) Minute pattern of human perspiration observed by a continuously recording method. Jpn J Physiol 9:359–364Google Scholar
  18. Ogawa T, Bullard RW (1972) Characteristics of subthreshold sudomotor neural impulses. J Appl Physiol 33:300–305Google Scholar
  19. Ogawa T, Terada E, Kobayashi M, Takagi K (1965) Variations of the electric conductivity of the skin in relation to sweating. Jpn J Physiol 15:296–309Google Scholar
  20. Snedecor GW, Cochran WG (1967) Statistical Methods, 6th edn. Iowa State University Press, Ames, IowaGoogle Scholar
  21. Sugenoya J, Ogawa T (1985) Characteristics of central sudomotor mechanism estimated by frequency of sweat expulsions. Jpn J Physiol 35:783–794Google Scholar
  22. Tainio H, Vaalasti A, Rechardt L (1987) The distribution of substance P-, CGRP-, galanin- and ANP-like immunoreactive nerves in human sweat glands. Histochem J 19:375–380Google Scholar
  23. Wilcott RC (1962) Palmar skin sweating vs. palmar skin resistance and skin potential. J Comp Physiol Psychol 55:327–331Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • J. Sugenoya
    • 1
  • S. Iwase
    • 2
  • T. Mano
    • 2
  • T. Ogawa
    • 1
  1. 1.Department of PhysiologyAichi Medical UniversityNagakute, AichiJapan
  2. 2.Department of Aerospace Psychology, Research Institute of Environmental MedicineNagoya UniversityNagoyaJapan

Personalised recommendations