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Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5

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Abstract

The mouse homologs of the Huntington's disease (HD) gene and 17 other human Chromosome (Chr) 4 loci (including six previously unmapped) were localized by use of an interspecific cross. All loci mapped in a continuous linkage group on mouse Chr 5, distal to En2 and Il6, whose human counterparts are located on Chr y. The relative order of the loci on human Chr 4 and mouse Chr 5 was maintained, except for a break between D5H4S115E and Idua/rd, with relocation of the latter to the opposite end of the map. The mouse HD homolog (Hdh) mapped within a cluster of seven genes that were completely linked in our data set. In human these loci span a∼1.8 Mb stretch of human 4p 16.3 that has been entirely cloned. To date, there is no phenotypic correspondence between human and mouse mutations mapping to this region of synteny conservation.

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Authors and Affiliations

  1. Molecular Neurogenetics Unit, Massachusetts General Hospital, 02129, Charlestown, Massachusetts, USA

    C. L. S. Grosson, M. E. MacDonald, M. P. Duyao, C. M. Ambrose & J. F. Gusella

  2. Department of Genetics, Harvard Medical School, 02114, Boston, Massachusetts, USA

    C. L. S. Grosson, M. E. MacDonald, M. P. Duyao, C. M. Ambrose & J. F. Gusella

  3. Neuroscience Program, Tuffs University School of Medicine, 02111, Boston, Massachusetts, USA

    S. Roffler-Tarlov

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  1. C. L. S. Grosson
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  2. M. E. MacDonald
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  3. M. P. Duyao
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  4. C. M. Ambrose
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  5. S. Roffler-Tarlov
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  6. J. F. Gusella
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Grosson, C.L.S., MacDonald, M.E., Duyao, M.P. et al. Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5. Mammalian Genome 5, 424–428 (1994). https://doi.org/10.1007/BF00357002

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