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Isolation of two murine H1 histone genes and chromosomal mapping of the H1 gene complement

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Abstract

The mammalian H1 histone gene complement consists of at least seven H1 protein isoforms. These include five S-phase-dependent H1 protein subtypes and two more distantly related proteins, which are expressed upon terminal differentiation (H10) or during the pachytene stage of spermatogenesis (H1t). In the past, three replication-dependent murine H1 genes plus the H1 0 and H1t genes have been isolated and characterized. In this report, we describe the sequences of two more H1 genes, and we show that all five murine replication-dependent H1 genes and the H1t gene map to the region A2-3 on Chromosome (Chr) 13. This is in agreement with our previous finding that the human H1 histone gene complement maps to 6p21.3, which corresponds to the A2-3 region on the murine Chr 13. Previous reports have shown that the replication-independent H1 0 genes map to syntenic regions on Chrs 22 (human H10) and 15 (murine H1 0).

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Authors and Affiliations

  1. Institut für Biochemie und Molekulare Zellbiologie, Georg-August-Universität Göttingen, Humboldtallee 23, D-37073, Göttingen, Germany

    B. Drabent, K. Franke, C. Bode, U. Kosciessa, H. Bouterfa & D. Doenecke

  2. Abteilung Medizinische Genetik, Universität Ulm, Albert-Einstein-Allee 11, D-89069, Ulm, Germany

    H. Hameister

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  1. B. Drabent
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  2. K. Franke
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  3. C. Bode
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  4. U. Kosciessa
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  5. H. Bouterfa
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  6. H. Hameister
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  7. D. Doenecke
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Drabent, B., Franke, K., Bode, C. et al. Isolation of two murine H1 histone genes and chromosomal mapping of the H1 gene complement. Mammalian Genome 6, 505–511 (1995). https://doi.org/10.1007/BF00356166

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  • DOI: https://doi.org/10.1007/BF00356166

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