Abstract
A total of 57 different microsatellite variants have been typed in one or more of five different sets of recombinant inbred (RI) mouse strains. The present report concentrates on markers for Chromosomes (Chrs) 10, 16, 18, 19 and X. These markers extend the regions swept in these RI strains, provide reference markers for integrating RI and conventional maps, and provide additional estimates of genetic distances. Multilocus maps, based on maximum likelihood analysis of present and previously published RI SDPs on five chromosomes, are presented. Unexpectedly, three microsatellite markers, previously assigned to Chr 10, detected polymorphic fragments mapping to other chromosomes.
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Cornall, R.J., Aitman, T.J., Hearne, C.M., Todd, J.A. (1991). The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome. Genomics 10, 874–881.
Cornall, R.J., Friedman, J.M., Todd, J., Friedman, J. (1992). Mouse microsatellites from a flow-sorted 4:6 Robertsonian chromosome. Mamm. Genome 3, 620–624.
Dietrich, W., Katz, H., Lincoln, S.E., Shin, H.-S., Friedman, J., Dracopoli, N., Lander, E.S. (1992). A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 131, 423–447.
Dietrich, W.F., Miller, J.C., Steen, R.G., Merchant, M., Damron, D., Nahf, R., Gross, A., Joyce, D.C., Wessel, M., Dredge, R.D., Marquis, A., Stein, L.D., Goodman, N., Page, D.C., Lander, E.S. (1994). A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genet. 7, 220–245.
Dower, N.A., Seldin, M.F., Pugh, S., Stone, J.C. (1992). Organization and chromosomal locations of Rap1a/Krev sequences in the mouse. Mamm. Genome 3, 162–167.
Eicher, E.M., Shown, E.P., Bhat, D., Seldin, M.F. (1993). Corrected centromere orientation for mouse Chromosome 19 MIT markers. Mamm. Genome 4, 223–225.
Haldane, J.B.S., Waddington, C.H. (1931). Inbreeding and linkage. Genetics 16, 357–374.
Hearne, C.M., McAleer, M.A., Love, J.M., Aitman, T.J., Cornall, R.J., Ghosh, S., Knight, A.M., Prins, J.-B., Todd, J.A. (1991). Additional microsatellite markers, for mouse genome mapping. Mamm. Genome 1, 273–282.
Lander, E.S., Green, P., Abrahamson, J., Barlow, A., Daly, M.J., Lincoln, S.E., Newburg, L. (1987). MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1, 174–181.
Reeves, R.H., Irving, N.G., Miller, R.D. (1993). Mouse Chromosome 16. Mamm. Genome 4(Suppl.), S223-S229.
Silver, J. (1985). Confidence limits for estimates of gene linkage based on analyses of recombinant inbred strains. J. Hered. 78, 436–440.
Taylor, B.A. (1978). Recombinant inbred strains: use in gene mapping. In Origins of Inbred Mice, H.C. Morse III, ed. (New York: Academic Press), pp. 423–438.
Taylor, B.A. (1995). Recombinant inbred strains. In Genetic Variants and Strains of the Laboratory Mouse, M.F. Lyon, S.D.M. Brown, eds. (Oxford University Press) (in press).
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Taylor, B.A., Phillips, S.J. Typing recombinant inbred mouse strains for microsatellite markers on Chromosomes 10, 16, 18, 19, and X. Mammalian Genome 6, 493–498 (1995). https://doi.org/10.1007/BF00356164
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DOI: https://doi.org/10.1007/BF00356164