Abstract
The btm (brachyury-interacting tail length modifier) mutation was discovered in strain MOL-NIS derived from Japanese wild mice (Mus musculus molossinus) as an autosomal recessive mutation. Homozygotes for this mutation show a short tail phenotype and, moreover, this mutation causes the tailless character by interacting with the T (brachyury) gene on Chromosome (Chr) 17. Our linkage tests and RFLP analyses suggest that btm is located within the t complex on Chr 17 and represents a new partial t haplotype.
Similar content being viewed by others
References
Agulnik, A.I., Ruvinsky, A.O., Polyakov, A.V. (1990). tct N mutation causing taillessness in mice heterozygous for T gene. Genetika 26, 1462–1468.
Bennett, D. (1975). The T-locus of the mouse. Cell 6, 441–454.
Bennett, D., Dunn, L.C., Artzt, K. (1976). Genetic change in mutations at the T/t locus in the mouse. Genetics 83, 361–372.
Committee for Chromosome 17: Maps of mouse Chromosome 17: first report. (1991). Mamm. Genome 1, 5–29.
Dobrovolskaia-Zavadskaia, N. (1927). Sur la mortification spontaneede la queue chez la souris nouveau-nee et sur la existence d'un caractere (facteur hereditaire) non-viable. C.R. Soc. Biol. 97, 114–117.
Dobrovolskaia-Zavadskaia, N., Kobozieff, N. (1932). Les souris anoures et la queue filiforme qui se reproduisent entres elles sans disjunction. C.R. Soc. Biol. 110, 782–784.
Erhart, M.A., Phillips, S.J., Bonhomme, F., Boursot, P., Wakeland, E.K., Nadeau, J.H. (1989). Haplotypes that are mosaic for wild-type and t complex-specific alleles in wild mice. Genetics 123, 405–415.
Figueroa, F., Neufeld, E., Ritte, U., Klein, J. (1988). t-specific DNA polymorphisms among wild mice from Israel and Spain. Genetics 119, 157–160.
Fujimoto, A., Baba, N., Wakasugi, N. (1991). A tail length modifier gene discovered in the Japanese wild mice (Mus musculus molossinus). Jpn. J. Genet. 66, 141–154.
Fujimoto, A., Wakasugi, N., Tomita, T. (1994). The developmental and morphological studies on the neural and skeletal abnormalities in the T/btm tailless mice. Dev. Growth & Differ. 36, 409–417.
Hammer, M.F., Schimenti, J., Silver, L.M. (1989). Evolution of mouse chromosome 17 and the origin of inversions associated with t haplotypes. Proc. Natl. Acad. Sci. USA 86, 3261–3265.
Herrmann, B., Bućan, M., Mains, P.E., Frischauf, A.-M., Silver, L.M., Lehrach, H. (1986). Gene analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t-haplotypes. Cell 44, 469–476.
Herrmann, B.G., Barlow, D.P., Lehnach, H. (1987). A large inverted duplication allows homologous recombination between chromosomes heterozygous for the proximal t complex inversion. Cell 48, 813–825.
Klein, J., Spipos, P., Figueroa, F. (1984). Polymorphism of t-complex genes in European wild mice. Genet. Res. 44, 39–46.
Lenington, S., Heisler, I.L. (1991). Behavioral reduction in the transmission of deleterious t haplotypes by wild house mice. Am. Nat. 137, 366–378.
Lyon, M.F., Mason, I. (1977). Information on the nature of t-haplotypes from the interaction of mutant haplotypes in male fertility and segregation ratio. Genet. Res. 29, 255–266.
Lyon, M.F., Meredith, R. (1964). The nature of t-alleles in the mouse. I. Genetic analysis of a series of mutants derived from a lethal allele. Heredity 19, 301–312.
Maniatis, T., Fritsch, E.F., Sambrook, J. (1989). Molecular Cloning: A Laboratory Manual, 2nd ed. (Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press).
Nadeau, J.H., Varnum, D., Burkart, D. (1989). Genetic evidence for two t complex tail interaction (tct) loci in t haplotypes. Genetics 122, 895–903.
Ruvinsky, A., Polyakov, A., Agulnik, A., Tichy, H., Figueroa, F., Klein, J. (1991). Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L. Genetics 127, 161–168.
Sakaizumi, M. (1989). t-Chromosome found in East Asiatic Wild mice, M. m. molossinus and M. m. castaneus. Mouse News Lett. 84, 119–120.
Shin, H.-S., Bennett, D., Artzt, K. (1984). Gene mapping within the T/t complex of the mouse. IV: The inverted MHC is intermingled with several t-lethal genes. Cell 39, 573–578.
Shiroishi, T., Sagai, T., Moriwaki, K. (1981). A simplified micro-method for cytotoxicity testing using a flat-type titration plate for detection of H-2 antigen. Microbiol. Immunol. 25, 1327–1334.
Silver, L.M. (1985). Mouse t haplotypes. Annu. Rev. Genet. 19, 179–208.
Vojtíšková, M., Viklický, V., Voráčová, B., Lewis, S.E., Gluecksohn-Waelsch, S. (1976). The effects of a t-allele (t AE5) in the mouse on the lymphoid system and reproduction. J. Embryol. Exp. Morphol. 36, 443–451.
Yanagisawa, K.O., Koyama, Y. (1982). t M, a new viable t-mutant in the mouse. Jpn. J. Genet. 57, 419–421.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fujimoto, A., Wakasugi, N. & Tomita, T. A novel partial t haplotype with a Brachyury-independent effect on tail phenotype. Mammalian Genome 6, 396–400 (1995). https://doi.org/10.1007/BF00355639
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00355639