Abstract
Growth arrest in NIH3T3 cells is associated with increased expression of a variety of mRNAs, several of which have been isolated as cDNA clones. Six of these growth arrest-specific (Gas) genes were mapped by following the inheritance of DNA restriction fragment length variants (RFLVs) associated with them in panels of recombinant inbred (RI) strains of mice and in the progeny of backcrosses both between laboratory mouse strains and between a laboratory strain and Mus spretus. The six genes are unlinked. Gas-1 maps to Chromosome (Chr) 13, Gas-2 to Chr 7, Gas-3 to Chr 11, Gas-4 to Chr 16, Gas-6 to Chr 8, and Gas-10 to Chr 1.
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References
Aruffo, A. and Seed, B.: Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc Natl Acad Sci USA 84: 8573–8577, 1987.
Bishop, D.: The information content of phase-known matings for ordered genetic loci. Genet Epidemiol 2: 349–361, 1985.
Blank, R.D., Campbell, G.R., Calabro, A., and D'Eustachio, P.: A linkage map of mouse chromosome 12: Localization of Igh and effects of sex and interference on recombination. Genetics 120: 1073–1083, 1988.
Brunet, J.F., Denizot, F., Lucianai, M.F., Roux-Dosseto, M., Suzan, M., Mattei, M.F., and Golstein, P.: A new member of the immunoglobulin superfamily CTLA-4. Nature 328: 267–270, 1987.
Crouse, G.F., McEwan, R.N., and Pearson, M.L.: Expression and amplification of engineered mouse dihydrofolate reductase minigenes. Mol Cell Biol 3: 257–266, 1983.
Davis, R.L., Weintraub, H., and Lasser, A.B.: Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51: 987–1000, 1987.
Ellis, R.W., DeFeo, D., Shih, T.Y., Gonda, M.A., Young, H.A., Tsuchida, N., Lowy, D.R., and Scolnick, E.M.: The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature 292: 506–511, 1981.
Frankel, W.N., Stoye, J.P., Taylor, B.A., and Coffin, J.M.: Genetic analysis of endogenous xenotropic murine leukemia viruses: Association with two common mouse mutations and the viral restriction locus Fv-1. J Virol 63: 1763–1774, 1989.
Fresco, L.D., Kurilla, M.G., and Keene, J.D.: Rapid inhibition of processing and assembly of small nuclear ribonucleoproteins after infection with vesicular stomatitis virus. Mol Cell Biol 7: 1148–1155, 1987.
Fung, M.C., Hapel, A.J., Ymer, S., Cohen, D.R., Johnson, R.M., Campbell, H.D., and Young, I.G.: Molecular cloning of cDNA for murine interleukin 3. Nature 307: 233–237, 1984.
Jenkins, J.R., Rudge, K., Redmond, S., and Wade-Evans, A.: Cloning and expression analysis of full length mouse cDNA sequences encoding the transformation associated protein p53. Nucl Acids Res 12: 5609–5626, 1984.
Lee, B.K., and Eicher, E.M.: Segregation patterns of endogenous mouse mammary tumor viruses in five recombinant inbred strain sets. J Virol 64: 4568–4572, 1990.
Major, J.E., and Varmus, H.E.: Nucleotide sequences at host-proviral junction for mouse mammary tumor virus. Nature 289: 253–258, 1981.
Malo, D., Schurr, E., Levenson, R., and Gros, P.: Assignment of the Na,K-ATPase β2-subunit gene (Atpb-2) to mouse chromosome 11. Genomics 6: 697–699, 1990.
Mock, B., Kozak, C., Seldin, M.F., Ruff, N., D'Hoostelaere, L., Szpirer, C., O'Brien, S., and Banner, C.: A glutaminase (GLS) gene maps to mouse chromosome 1, rat chromosome 9, and human chromosome 2. Genomics 5: 291–297, 1989.
Nicholls, R.D.: A cDNA from proximal human chromosome 15q maps near Mtv-1 on mouse chromosome 7. Mouse News Lett 84: 87–88, 1989.
Rickles, R.J., Darrow, A.L., and Strickland, S.: Molecular cloning of complementary DNA to mouse tissue plasminogen activator mRNA and its expression during F9 teratocarcinoma cell differentiation. J Biol Chem 263: 1563–1569, 1988.
Schneider, C., King, R.M., and Phillipson, L.: Genes specifically expressed at growth arrest of mammalian cells. Cell 54: 787–793, 1988.
Seldin, M.F., Morse, H.C., Reeves, J.P., Scriber, C.L., LeBoeuf, R.C., and Steinberg, A.D.: Genetic analysis of “autoimmune” gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group. J Exp Med 167: 688–693, 1988.
Silver, J.: Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains. J Hered 76: 436–440, 1985.
Skow, L.C., Adkison, L., Womack, J.E., Beamer, W.G., and Taylor, B.A.: Mapping of the mouse fibronectin gene (Fn-1) to Chromosome 1: Conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals. Genomics 1: 283–286, 1987.
Sola, B., Simon, D., Mattei, M.-G., Fichelson, S., Bordereaux, D., Tambourin, P.E., Guénet, J.-L., and Gisselbrecht, S.: Fim-1, Fim-2/c-Fms, and Fim-3, three common integration sites of Friend murine leukemia virus, map to mouse chromosomes 13, 18, and 3, respectively. J Virol 62: 3973–3978, 1988.
Stewart, G.D., Harris, P., Galt, J., and Ferguson-Smith, M.A.: Cloned DNA probes originally mapped to human chromosome 21 and their use in determining the origin of nondisjunction. Nucl Acids Res 13: 4125–4132, 1985.
Taylor, B.A.: Recombinant inbred strains. In M.F. Lyon and A.G. Searle (eds.); Genetic Variants and Strains of the Laboratory Mouse, Second Edition, pp. 773–796, Oxford University Press, New York, 1989.
Taylor, B.A. and Rowe, L.: Mapping the Fes proto-oncogene locus. Mouse News Lett 83: 167–168, 1989.
Ullrich, A., Bell, J.R., Chen, E.Y., Herrera, R., Petruzzelli, L.M., Dull, T.J., Gray, A., Coussens, L., Liao, Y.-C., Tsubokawa, M., Mason, A., Seeburg, P.H., Grunfeld, C., Rosen, O.M., and Ramachandran, J.: Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313: 756–761, 1985.
Ullrich, A., Gray, A., Tam, A.W., Yang-Fen, T., Tsubokawa, M., Collins, C., Henzel, W., LeBon, T., Kathuria, S., Chen, E., Jacobs, S., Franck, U., Ramachandran, J., and Fujita-Yamaguchi, Y.: Insulin-like growth factor I receptor's primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 5: 2503–2512, 1986.
Watson, D.K., Kozak, C., Smith, M.J., Reeves, R.H., Gearhart, J.D., Papas, T.S., Nash, W., Modi, W., Duesberg, P., and O'Brien, S.J.: Conservation of the chromosomal positions of disparate 5′ and 3′ domains of the ets protooncogene in cats, mice, and men. Proc Natl Acad Sci USA 83: 1792–1796, 1986.
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Colombo, M.P., Martinotti, A., Howard, T.A. et al. Localization of growth arrest-specific genes on mouse Chromosomes 1, 7, 8, 11, 13, and 16. Mammalian Genome 2, 130–134 (1992). https://doi.org/10.1007/BF00353861
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DOI: https://doi.org/10.1007/BF00353861