Skip to main content
Log in

Characterization of the endogenous nonecotropic murine leukemia viruses of NZB/BINJ and SM/J inbred strains

  • Original Contributions
  • Published:
Mammalian Genome Aims and scope Submit manuscript

Abstract

We characterized 84 endogenous nonecotropic proviruses of NZB/B1NJ and SM/J inbred strains by examining proviral junction fragment segregation in recombinant inbred (RI) and backcross mice. Forty-five proviruses were shared with other laboratory strains, but 28 were unique to NZB/BINJ or SM/J. Proviral loci were located on 17 of the 19 mouse autosomes and on both sex chromosomes. These markers will facilitate gene mapping in the NXSM RI set and contribute to the pursuit of a more complete map of the mouse genome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Ann, D.K. and Carlson, D.M.: The structure and organization of a proline-rich protein gene of a mouse multigene family. J Biol Chem 260: 15863–15872, 1985.

    Google Scholar 

  • Baehr, W., Falk, J.D., Bugna, K., Triantafyllos, J.T., and McGinnis, J.F.: Isolation and analysis of the mouse opsin gene. FEBS Lett 238: 253–256, 1988.

    Google Scholar 

  • Blatt, C., Mileham, K., Haas, M., Nesbitt, M.N., Harper, M.E., and Simon, M.I.: Chromosomal mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse. Proc Natl Acad Sci USA 80: 6298–6302, 1983.

    Google Scholar 

  • Bosselman, R.A., van Straaten, F., Van Beveren, C., Verma, I.M., and Vogt, M.: Analysis of the env gene of a molecularly cloned and biologically active Moloney mink cell focus-forming proviral DNA. J Virol 44: 19–31, 1982.

    Google Scholar 

  • Buckler, C.E., Hoggan, M.D., Chan, H.W., Sears, J.F., Khan, A.S., Moore, J.L., Hartley, J.W., Rowe, W.P., and Martin, M.A.: Cloning and characterization of an envelope-specific probe from xenotropic murine leukemia proviral DNA. J Virol 41: 228–236, 1982.

    Google Scholar 

  • Ch'ang, L., Yang, W.K., Myer, F.E., Koh, C.K., and Boone, L.R.: Specific sequence deletions in two classes of murine leukemia virus-related proviruses in the mouse genome. Virology 168: 245–255, 1989.

    Google Scholar 

  • Chattopadhyay, S.K., Lander, M.R., Gupta, S., Rands, E., and Lowy, D.R.: Origin of mink cytopathic focus-forming (MCF) viruses: Comparison with ecotropic and xenotropic murine leukemia virus genomes. Virology 113: 465–483, 1981.

    Google Scholar 

  • Drivas, G., Massey, R., Chang, H.-Y., Rush, M.G., and D'Eustachio, P.: Ras-like genes and gene families in the mouse. Mammalian Genome 1: 112–117, 1991.

    Google Scholar 

  • Eicher, E.M., Hutchinson, K.W., Phillips, S.J., Tucker, P.K., and Lee, B.K.: A repeated segment on the mouse Y chromosome is composed of retroviral-related, Y-enriched and Y-specific sequences. Genetics 122: 181–192, 1989.

    Google Scholar 

  • Eicher, E.M. and Lee, B.K.: The NXSM recombinant inbred strains of mice: Genetic profile for 58 loci including the Mtv proviral loci. Genetics 125: 431–446, 1990.

    Google Scholar 

  • Frankel, W.N., Stoye, J.P., Taylor, B.A., and Coffin, J.M.: Genetic analysis of endogenous xenotropic MLVs: Association with two common mouse mutations and the viral restriction locus Fv-1. J Virol 63: 1762–1774, 1989a.

    Google Scholar 

  • Frankel, W.N., Stoye, J.P., Taylor, B.A., and Coffin, J.M.: Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice. J Virol 63: 3810–3821, 1989b.

    Google Scholar 

  • Frankel, W.N., Stoye, J.P., Taylor, B.A., and Coffin, J.M.: A genetic linkage map of endogenous murine leukemia proviruses. Genetics 124: 221–236, 1990.

    Google Scholar 

  • Gerstein, R.M., Frankel, W.N., Hseih, C., Durdik, J.M., Rath, S., Coffin, J.M., Nisonoff, A., and Selsing, E.: Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes. Cell 63: 537–548, 1990.

    Google Scholar 

  • Hoggan, M.D., O'Neill, R.R., and Kozak, C.A.: Nonecotropic murine leukemia viruses in BALB/c and NFS/N mice: Characterization of the BALB/c Bxv-1 provirus and the single NFS endogenous xenotrope. J Virol 60: 980–986, 1986.

    Google Scholar 

  • Isenberg, K.E., Mudd, J., Shah, V., and Merlie, J.P.: Nucleotide sequences of the mouse muscle nicotinic acetylcholine receptor a subunit. Nucl Acids Res 14: 5111, 1986.

    Google Scholar 

  • Morse III, H.: The laboratory mouse: A historical perspective. In H.L. Foster, J.D. Small and J.G. Fox (eds.), The Mouse in Biomedical Research, pp. 1–16, Academic Press, Inc., New York, 1981.

    Google Scholar 

  • Morse III, H.C.: Historical perspective on the development of inbred mice. In H.C. Morse III (ed.), Origins of Inbred Mice, pp. 1–21, Academic Press, New York, 1978.

    Google Scholar 

  • Neumann, P.E.: Two-locus linkage analysis using recombinant inbred strains and Bayes' theorem. Genetics 126: 277–284, 1990.

    Google Scholar 

  • Nikbakht, K.N., Boone, L.R., Glover, P.L., Myer, F.E., and Yang, W.K.: Characterization of a molecular clone of RFM/Un mouse chromosomal DNA that contains a full-length endogenous murine leukemia virus-related proviral genome. J Gen Virol 68: 683–693, 1987.

    Google Scholar 

  • O'Neill, R.R., Khan, A.S., Hoggan, M.D., Hartley, J.W., Martin, M.A., and Repaske, R.: Specific hybridization probes demonstrate more MCF than xenotropic MuLV env related sequences in DNAs from inbred laboratory mice. J Virol 58: 359–366, 1986.

    Google Scholar 

  • Rickles, R.J., Darrow, A.J., and Strickland, S.: Molecular cloning of complementary DNA to mouse tissue plasminogen activator mRNA and its expression during F9 teratocarcinoma cell differentiation. J Biol Chem 263: 1563–1569, 1988.

    Google Scholar 

  • Rise, M., Frankel, W.N., Coffin, J.M., and Seyfried, T.N.: Genes for epilepsy mapped in the mouse. Science 253: 669–673, 1991.

    Google Scholar 

  • Silver, J.: Confidence limits for estimates of gene linkage based on analyses of recombinant inbred strains. J Hered 78: 436–440, 1985.

    Google Scholar 

  • Siracusa, L.D., Jenkins, N.A., and Copeland, N.G.: Identification and applications of repetitive probes for gene mapping in the mouse. Genetics 127: 169–179, 1991.

    Google Scholar 

  • Stoye, J.P. and Coffin, J.M.: The four classes of endogenous murine leukemia virus: Structural relationships and potential for recombination. J Virol 61: 2659–2669, 1987.

    Google Scholar 

  • Stoye, J.P., and Coffin, J.M.: Polymorphism of murine endogenous proviruses revealed by using virus class-specific oligonucleotide probes. J Virol 62: 168–175, 1988.

    Google Scholar 

  • Taylor, B.A.: Recombinant inbred strains: Use in gene mapping. In H.C. Morse III (ed.), Origins of Inbred Mice, pp. 423–438, Academic Press, New York, 1978.

    Google Scholar 

  • Taylor, B.A. and Rowe, L.: A mouse linkage testing stock possessing multiple copies of the endogenous ecotropic murine leukemia virus genome. Genomics 5: 221–232, 1989.

    Google Scholar 

  • Villani, V., Coffino, P., and D'Eustachio, P.: Linkage genetics of mouse ornithine decarboxylase (Odc). Genomics 5: 636–638, 1989.

    Google Scholar 

  • Wejman, J.C., Taylor, B.A., Jenkins, N.A., and Copeland, N.G.: Endogenous xenotropic murine leukemia virus-related sequences map to chromosomal regions encoding mouse lymphocyte antigens. J Virol 50: 237–247, 1984.

    Google Scholar 

  • Xiang, X., Benson, K.F., and Chada, K.: Mini-mouse: Disruption of the pygmy locus in a transgenic insertional mutant. Science 247: 967–969, 1990.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Frankel, W.N., Lee, B.K., Stoye, J.P. et al. Characterization of the endogenous nonecotropic murine leukemia viruses of NZB/BINJ and SM/J inbred strains. Mammalian Genome 2, 110–122 (1992). https://doi.org/10.1007/BF00353859

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00353859

Keywords

Navigation