Abstract
Squamous cell carcinoma (SCC) of the thyroid is thought to be rare. However, SCC not infrequently occurs in conjunction with other histologic types of tumor. We reviewed 67 thyroid cancer autopsy cases obtained from two institutions from 1969 to 1981 and from 1975 to 1992, respectively. SCC was found in 19 cases (28.4%): 2 SCCs as the only malignancy and of uniform histologic type, 9 cases of tumors mixed with papillary carcinoma, and 8 cases of SCC mixed with papillary and anaplastic carcinomas. In only four of these cases was the SCC component found in the surgical specimens. These results indicate that the presence of SCC component is more likely to be found at the later stage of the disease.
Résumé
Le cancer épithélial (CE) de la thyroïde est extrêmement rare. Cependant, le CE associé à d'autres types histologiques de tumeur se voit plus souvent. Nous avons analysé 67 cas de cancer de la thyroïde provenant des autopsies de deux institutions entre respectivement, 1969 et 1981 et 1975 et 1992. Il y avait 19 cas de CE (28.4%). Parmi ceux-ci, le CE était la seule tumeur maligne et était de type histologique uniforme dans deux cas. Il y avait neuf cas de CE et de cancer papillaire, et 8 cas de CE associé à un cancer papillaire et anaplasique. Le composant CE, cependant, n'a été retrouvé sur la pièce opératoire que dans quatre cas. Ces résultats indiquent qu'il est probable que le composant CE se révèle à un stade plus tardif de l'évolution.
Resumen
El carcinoma escamocelular (CEC) de la glándula tiroides es considerado como un tumor extremadamente raro. Sin embargo, el CEC coincidente con tumores de otros tipos histológicos no es infrecuente.
Revisamos 67 autopsias de cáncer tiroidea practicadas en dos instituciones entre 1969 y 1981 y entre 1975 y 1992, respectivamente. Se halló CEC en 19 casos (28.4%): en 2 el CEC apareció como el único neoplasma maligno y con un tipo histológico uniforme, en 9 casos mezclado con carcinoma papilar y en 8 mezclado con carcinomas papilar y anaplásico.
En sólo 4 de estos casos se encontró el componente de CEC en los especímenes quirúrgicos. Tales resultados indican que la presencia del componente CEC es más probable que sea hillado en las etapas tardías de la enfermedad.
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References
Goldman, R.L.: Primary squamous cell carcinoma of the thyroid gland: report of a case and review of literature. Am. Surg. 30:247, 1964
Saxen, E.: Squamous metaplasia in the thyroid gland and histogenesis of epidermoid carcinoma of the thyroid. Acta Pathol. Microbiol. Immunol. Scand. 28:55, 1951
Katagiri, M., Yamane, Y., Yasuda, K., Harada, T., Tsukayama, C.: Squamous cell carcinoma originating in the thyroid gland—report of two cases and a review of literature. J. Jpn. Soc. Clin. Surg. 50:2326, 1989 (Japanese)
Kurihara, T., Koyama, T., Ishida, T., et al.: A primary squamous cell carcinoma of the thyroid: an ultrastructural and immunohistological study of two cases. Jpn. J. Cancer Clin. 37:655, 1991 (Japanese)
Harada, T., Ito, K., Shimaoka, K, Hosoda, Y., Yakumaru, K.: Fatal thyroid carcinoma: anaplastic transformation of adenocarcinoma. Cancer 39:2588, 1977
Harada, T., Shimaoka, K., Yakumaru, K., Ito, K.: Squamous cell carcinoma of the thyroid gland: transition from adenocarcinoma. J. Surg. Oncol. 19:36, 1982
Harada, T., Katagiri, M., Tsukayama, C., Higashi, Y., Shimaoka, K.: Squamous cell carcinoma with cyst of the thyroid. J. Surg. Oncol. 42:136, 1989
Shimaoka, K., Tsukada, Y.: Squamous cell carcinoma and adenosquamous carcinoma originating from the thyroid gland. Cancer 46:1833, 1980
Report of Thyroid Malignant Tumor Registry presented at the 25th Annual Meeting of the Japanese Society of Thyroid Surgery, 1992 (Japanese)
Sakai, T.: Cancroid in thyroid gland. Hokuetsu Ishi 50:1271, 1935 (Japanese)
LiVolsi, V.A.: Pathology of thyroid cancer. In Thyroid Cancer, Greenfied, editor. West Palm Beach, FL, CRC Press, 1978, pp. 85–141
Hedinger, C., Sobin, L.H.: Histological typing of thyroid tumors. In International Histological Classification of Tumors, No. 11. Geneva, World Health Organization, 1974
Hedinger, C., Williams, E.D., Sobin, L.H.: In International Histological Classification of Tumors (2nd ed.). Berlin, Springer-Verlag, 1988
Smith, L.W., Pool, E.H., Olcott, C.T.: Malignant disease of the thyroid gland: clinicopathological analysis of 54 cases of thyroid malignancy. Cancer 20:1, 1934
Shephard, G.H., Rosenfeld, L.: Carcinoma of thyroglossal duct remnants. Am. J. Surg. 116:125, 1968
Korovin, G.S., Kuriloff, D.B., Cho, H.T., Sobol S.: Squamous cell carcinoma of the thyroid: a diagnostic dilemma. Ann. Otol. Laryngol. 98:59, 1989
Katoh, R., Sakamoto, A., Kasai, N., Yagawa, K.: Squamous differentiation in thyroid carcinoma with special reference to histogenesis of squamous cell carcinoma of the thyroid. Acta Pathol. Jpn. 38:306, 1989
Harcout-Webster, J.N.: Squamous epithelium in the human thyroid gland. J. Clin. Pathol. 19:384, 1966
Dube, V.E., Joyge, G.T.: Extreme squamous metaplasia in Hashimoto thyroiditis. Cancer 27:434, 1971
Klink, G.H., Menk, K.F.: Squamous cell in the human thyroid. Milit. Surg. 109:406, 1951
Jaffe, R.H.: Epithelial metaplasia of the thyroid gland; with special reference to the histogenesis of squamous cell carcinoma of the thyroid gland. Arch. Pathol. 23:821, 1937
Meissner, W.A., Warren, S.: Tumor of the thyroid gland. In Atlas of Tumor Pathology, Series 2, Fasc. 4. Washington, DC, Armed Forces Institute of Pathology, 1969
Lindsay, S.: Carcinoma of the thyroid gland: a clinical and pathologic study of 293 patients at University of California Hospital. Springfield, IL, Charles C Thomas, 1960, pp. 52–58
Carcangiu, M.L., Steeper, T., Zampi, G., Rosai, J.: Anaplastic thyroid carcinoma: a study of 70 cases. Am. J. Clin. Pathol. 83:135, 1985
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Harada, T., Shimaoka, K., Katagiri, M. et al. Rarity of squamous cell carcinoma of the thyroid: Autopsy review. World J. Surg. 18, 542–546 (1994). https://doi.org/10.1007/BF00353760
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DOI: https://doi.org/10.1007/BF00353760