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Localization of genes for two members of the JAK family of protein tyrosine kinases to murine Chromosomes 4 and 19

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Abstract

Genes encoding two members of the JAK family of protein tyrosine kinases, Jak-1 and Jak-2, have been mapped to mouse Chromosomes (Chrs) 4 and 19 respectively. These placements are consistent with the previously described location of human JAK1 and JAK2, which lie in regions of synteny on human Chrs 1p31-3 (JAK1) and 9p24 (JAK2). The location of Jak-2 in the mouse genome extends the region of homology between mouse Chr 19 and human Chr 9.

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References

  • Chainani, M., Sampsell, B., Elliott, R.W. (1991). Localization of the gene for plasma retinol binding protein to the distal half of mouse chromosome 19. Genomics 9, 376–379.

    Google Scholar 

  • Crawford, R.J., Hudson, P., Shine J., Niall, H.D., Eddy R.L., Shows T.B. (1986). Two human relaxin genes are on chromosome 9. EMBO J. 3, 2341–2345.

    Google Scholar 

  • Fowler, K.J., Clouston, W.M., Fournier, R.E.K., Evans B.A. (1991). The relaxin gene is located on chromosome 19 in the mouse. FEBS Lett 292, 183–186.

    Google Scholar 

  • Frankel, W.W., Lee, B.K., Stoye, J.P., Coffin, J.M., Eicher, E.M. (1992). Characterization of the endogenous nonecotropic murine leukemia viruses of NZB/BINJ and SM/J inbred strains. Mamm. Genome 2, 110–122.

    Google Scholar 

  • Pritchard, M., Baker, E., Callen, D.F., Sutherland, G.R., Wilks, A.F. (1992). Two members of the JAK family of protein tyrosine kinases map to chromosome 1p31.3 and 9p24. Mamm. Genome 3, 36–38

    Google Scholar 

  • Silver J. (1985). Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains. J. Hered. 76, 436–440.

    Google Scholar 

  • Taylor, B.A., Meier, H. (1976). Mapping the adrenal lipid depletion gene of the AKR/J mouse strain. Genet. Res. 26, 307–312.

    Google Scholar 

  • Wilks, A.F. (1993). Protein tyrosine kinases, growth factor receptors and their ligands in development, differentiation and cancer. Adv. Cancer Res. 60, 43–73.

    Google Scholar 

  • Wilks, A.F., Harpur, A.G., Kurban, R.R., Ralph, S.J., Zurcher, G., Ziemiecki, A. (1991). Two novel protein tyrosine kinases each with a second phosphotransferase-releted catalytic domain define a new class of protein kinase. Mol. Cell. Biol. 11, 2057–2065.

    Google Scholar 

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Gough, N.M., Rakar, S., Harpur, A. et al. Localization of genes for two members of the JAK family of protein tyrosine kinases to murine Chromosomes 4 and 19. Mammalian Genome 6, 247–248 (1995). https://doi.org/10.1007/BF00352409

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  • DOI: https://doi.org/10.1007/BF00352409

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